0000000000760717
AUTHOR
Christoph Jan Wruck
Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals
Abstract Allergic contact dermatitis is induced by repeated skin contact with an allergen. Assessment of the skin sensitizing potential of chemicals, agrochemicals, and especially cosmetic ingredients is currently performed with the use of animals. Animal welfare and EU legislation demand animal-free alternatives reflected in a testing and marketing ban for cosmetic ingredients beginning in 2013. The underlying mechanisms of induction and elicitation of skin sensitization are complex and a chemical needs to comply several properties being skin sensitizing. To account for the multitude of events in the induction of skin sensitization an in vitro test system will consist of a battery of vario…
Nrf2 expression driven by Foxp3 specific deletion of Keap1 results in loss of immune tolerance in mice
European journal of immunology 50(4), 515-524 (2020). doi:10.1002/eji.201948285