0000000000761557

AUTHOR

S. Siracusano

showing 6 related works from this author

Postoperative nomogram for invasive bladder cancer: does it really work? A multicenter cohort study.

2011

Objectives: Nomograms are statistical models designed to maximize predictive accuracy. We have tested the statistical correlation between the predictions of International Bladder Cancer Nomogram Consortium and the clinical outcomes in a multicenter Italian cohort of patients treated with radical cystectomy (RC) and pelvic lymph-nodes dissection. Methods and materials: Two hundred four patients who underwent RC were selected for multiple variable and then enrolled in the study. Patients were tested by the "online tool" based on the nomogram, then stratified and risk grouped for 5-year predicted disease-free survival (pDFS): low risk (67%-100%), intermediate risk (34%-66%), and high risk grou…

Malemedicine.medical_treatmentKaplan-Meier EstimatePostoperative nomogramNomogramCohort StudiesRetrospective StudieArea under curvePostoperative Periodinvasive bladder cancer; Postoperative nomogramAged 80 and overSettore MED/24 - UROLOGIAinvasive bladder cancerMiddle AgedPrognosisOncologyArea Under CurveUrinary Bladder NeoplasmCohortFemaleHumanCohort studyAdultmedicine.medical_specialtyPrognosiUrologyUrologyCystectomyDisease-Free SurvivalCystectomymedicineHumansAgedNeoplasm StagingRetrospective StudiesCarcinoma Transitional CellBladder cancerbusiness.industryRetrospective cohort studyNomogrammedicine.diseaseRadical cystectomyNomogramsROC CurveUrinary Bladder NeoplasmsCohort StudieNeoplasm GradingPredictionbusinessStatistical correlationUrologic oncology
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Chromophobe renal cell carcinoma (RCC): oncological outcomes and prognostic factors in a large multicentre series.

2011

Study Type - Outcomes (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? About 80% of RCCs have clear cell histology, and consistent data are available about the clinical and histological characteristics of this histological subtype. Conversely, less attention has been dedicated to the study of non-clear cell renal tumours Specifically, published data show that chromophobe RCC (ChRCC) have often favourable pathological stages and better nuclear grades as well as a lower risk of metastasizing compared with clear cell RCC (ccRCC). Patients with ChRCC were shown to have significantly higher cancer-specific survival (CSS) probabilities compared with ccRCC. H…

Malerenal cell carcinomachromophobe RCC; prognostic factors; Carcinoma; Nephrectomy; Prognosis; Renal cellKaplan-Meier EstimateChromophobe renal cell carcinomaCarcinoma; Chromophobe; Nephrectomy; Prognosis; Renal cellchromophobe RCCNephrectomyHumansRenal cellCarcinoma Renal CellChromophobecarcinoma; renal cell; chromophobe; prognosis; nephrectomyCarcinomaKidney Neoplasmprognostic factorsMiddle AgedPrognosisKidney Neoplasmsoncological outcamesrenal cell carcinoma; prognostic factorsoncological outcomes and prognostic factorsChromophobe renal cell carcinoma; prognostic factors; oncological outcamesFemaleprognosiHuman
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External validation of the preoperative Karakiewicz nomogram in a large multicentre series of patients with renal cell carcinoma

2012

Purpose: To perform a formal external validation of the preoperative Karakiewicz nomogram (KN) for the prediction of cancer-specific survival (CSS) using a large series of surgically treated patients diagnosed with organ-confined or metastatic renal cell carcinoma (RCC). Methods: Patient population originated from a series of retrospectively gathered cases that underwent radical or partial nephrectomy between years 1995 and 2007 for suspicion of kidney cancer. The original Cox coefficients were used to generate the predicted risk of CSS at 1, 2, 5, and 10 years following surgery and compared to the observed risk of CSS in the current population. External validation was quantified using meas…

Malemedicine.medical_treatmentKarakiewicz NomogramPredictive Value of TestNephrectomyNomogramPreoperative nomogram; Renal cell carcinoma; Prognostic Factors; Partial Nephrectomy; Radical nephrectomy; Metastatic renal cell carcinomaRisk FactorsRenal cell carcinomaRetrospective StudieChildAged 80 and overeducation.field_of_studyRadical nephrectomyPrognostic FactorKidney NeoplasmMiddle AgedKidney NeoplasmsNephrectomyRenal cell carcinomaSurvival RateItalyPreoperative nomogramPredictive value of testsPreoperative PeriodFemalePartialHumanAdultmedicine.medical_specialtyKarakiewicz Nomogram; Renal cell carcinoma; cancer specific survivalAdolescentUrologyPopulationMetastatic renal cell carcinomacancer specific survivalUrologyYoung AdultPredictive Value of TestsmedicineHumanseducationSurvival rateCarcinoma Renal CellRetrospective StudiesAgedPrognostic Factorsbusiness.industryRisk FactorRetrospective cohort studyNomogramMetastatic renal cell carcinoma; Nephrectomy; Preoperative nomogram; Prognostic Factors; Renal cell carcinomamedicine.diseaseNomogramsbusinessKidney cancer
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Elective partial nephrectomy is equivalent to radical nephrectomy in patients with clinical T1 renal cell carcinoma: results of a retrospective, comp…

2012

Study Type - Therapy (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Few studies supported the expanded indications for nephron-sparing surgery (NSS) in selected patients with 4.1 cm renal tumours in the size range (T1b). However, all these comparative studies included both imperative and elective partial nephrectomy and patient selection for analysis was based on pathological stage (pT1) and not on clinical stage (cT1). Patients with clinically organ-confined RCC (cT1) who are candidates for elective PN have a limited risk of clinical understaging. NSS is not associated with an increased risk of recurrence and cancer-specific mortality both in cT1a a…

Malerenal cell carcinomapartial nephrectomyrenal cancerNephrectomymethodsElectiveclinical staging; nephron-sparing surgery; partial nephrectomy; radical nephrectomy; renal cancernephrectomyclinical stagingHumansCarcinoma Renal CellSurgical ProceduresElective Surgical ProcedureCarcinomanephron-sparing surgeryRenal CellElective partial nephrectomy is equivalent to radical nephrectomy in patients with clinical T1 renal cell carcinomaKidney NeoplasmMiddle AgedKidney NeoplasmsSurvival Ratemortality/pathology/surgeryElective Surgical Proceduresnephrectomy; renal cell carcinoma; nephron-sparing surgeryFemaleCarcinoma; Renal Cell; mortality/pathology/surgery Female Humans Kidney Neoplasms; mortality/pathology/surgery Male Middle Aged Nephrectomy; methods Surgical Procedures; Elective Survival RateHumanradical nephrectomy
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Time to recurrence is a significant predictor of cancer-specific survival after recurrence in patients with recurrent renal cell carcinoma - Results …

2013

Objectives To assess the prognostic impact of time to recurrence (TTR) on cancer-specific survival (CSS) after recurrence in patients with renal cell carcinoma (RCC) undergoing radical nephrectomy or nephron-sparing surgery. To analyse differences in clinical and histopathological criteria between patients with early and late recurrence. Patients and Methods Of 13 107 patients with RCC from an international multicentre database, 1712 patients developed recurrence in the follow-up (FU), at a median (interquartile range) of 50.1 (25-106) months. In all, 1402 patients had recurrence at ≤5 years (Group A) and 310 patients beyond this time (Group B). Differences in clinical and histopathological…

Malerenal cell carcinomaTime FactorsTime FactorDatabases FactualPrognosiUrologyprognostic parameterearly recurrencetime to recurrencecancer-specific survivalRetrospective Studielate recurrencenephrectomyHumanscancer survivalCarcinoma Renal Cellrenal cell carcinoma (RCC); time to recurrence; early recurrence; late recurrence; prognostic parameters; cancer-specific survival; nephrectomyAgedRetrospective StudiesKidney NeoplasmMiddle Agedprognostic parametersPrognosisKidney NeoplasmsSurvival Ratecancer survival; early recurrence; late recurrence; nephrectomy; prognostic parameters; renal cell carcinomacancer-specific survival; early recurrence; late recurrence; nephrectomy; prognostic parameters; renal cell carcinoma; time to recurrenceFemaleNeoplasm Recurrence Localrenal cell carcinoma (rcc)cancer-specific survival; early recurrence; late recurrence; nephrectomy; prognostic parameters; renal cell carcinoma (rcc); time to recurrenceHuman
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LA CISTECTOMIA “PROSTATE E SEMINAL SPARING” Pro: (Trieste) Contro: V. Serretta (Palermo)

2013

Il tumore della vescica rimane una delle neoplasie più frequenti nell’ambito dell’oncologia urologica. Le strategie diagnostiche si stanno sempre più evolvendo e ci permettono di caratterizzare sempre meglio la neoplasia. Durante il corso verranno illustrate alcune nuovissime tecniche diagnostiche apparse recentemente. Dal punto di vista terapeutico l’intervento chirurgico demolitivo, la cistectomia, è sicuramente l’approccio di scelta per i tumori non muscolo invasivi ad alto ed altissimo rischio e per i tumori infiltranti. Tuttavia le tecniche si sono evolute come pure la preparazione del paziente. Durante il corso verranno discusse e dibattute due delle più interessanti e recenti tecnich…

Vescica cistectomiaSettore MED/24 - Urologia
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