0000000000761759

AUTHOR

L. Comito

showing 3 related works from this author

17b-hydroxysteroid oxidoreductase activity in intact cells significantly differs from classical enzymology analysis

1996

17b-hydroxysteroid oxidoreductaseSettore BIO/10 - Biochimica
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Multiple Estrogen Function in Human Prostate Cancer Cells

1996

MalePCA3Oncologymedicine.medical_specialtyNeoplasms Hormone-DependentCell divisionmedicine.drug_classGeneral Biochemistry Genetics and Molecular BiologyHistory and Philosophy of ScienceHeat shock proteinInternal medicineTumor Cells CulturedAnimalsHumansMedicineHeat-Shock Proteinsbusiness.industryCadherinGeneral NeuroscienceProstatic NeoplasmsCancerEstrogensProstate-Specific AntigenCadherinsmedicine.diseaseRatsProstate-specific antigenReceptors EstrogenEstrogenCancer cellAndrogensbusinessCell DivisionAnnals of the New York Academy of Sciences
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Steroid-growth factor interaction in human prostate cancer. 1. Short-term effects of transforming growth factors on growth of human prostate cancer c…

1994

In order to better define potential mechanisms of growth regulation in human prostate cancer cells, we have compared biological responses (such as short-term response to both transforming growth factor alpha and beta; TFG alpha and TFG beta) in relation to hormone sensitivity of LNCaP, DU145, and PC3 cells. Androgen receptor (AR) and epidermal growth factor receptor (EGF-R) content of each cell line was also investigated. In addition, expression of EGF, TGF alpha, and TGF beta was evaluated through immunofluorescent staining. Growth of androgen non-responsive PC3 cells was stimulated by TGF alpha (about 35%) and inhibited by TGF beta (more than 50%), with respect to controls, after 48 h exp…

Malemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentClinical BiochemistryFluorescent Antibody Techniqueurologic and male genital diseasesBiochemistryProstate cancerEndocrinologyDU145Transforming Growth Factor betaInternal medicineLNCaPTumor Cells CulturedmedicineHumansReceptors Growth FactorEpidermal growth factor receptorMolecular BiologyPharmacologybiologyGrowth factorOrganic ChemistryProstatic NeoplasmsTransforming Growth Factor alphamedicine.diseaseAndrogen receptorEndocrinologyReceptors AndrogenCancer cellAndrogensbiology.proteinCell DivisionTransforming growth factorSteroids
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