0000000000762803

AUTHOR

Kamlesh Kumar

0000-0001-7374-5941

showing 4 related works from this author

Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization an…

2016

The synthesis and characterization of twenty new pentamethylcyclopentadienyl-rhodium and iridium complexes containing N^N and N^O-chelating chloroquine analogue ligands are described. The in vitro antimalarial activity of the new ligands as well as the complexes was evaluated against the chloroquine sensitive (CQS) NF54 and the chloroquine resistant (CQR) Dd2 strains of Plasmodium falciparum. The antimalarial activity was found to be good to moderate; although all complexes are less active than artesunate, some of the ligands and complexes showed better activity than chloroquine (CQ). In particular, rhodium complexes were found to be considerably more active than iridium complexes against t…

Models Molecularantimalarial propertiesStereochemistryPlasmodium falciparumDrug ResistanceMolecular Conformationchemistry.chemical_elementCrystal structureChemistry Techniques Synthetic010402 general chemistryIridiumLigands01 natural sciencesChlorideRhodiumIridium and Rhodium complexes chloroquine analog ligands Crystal structures in vitro antimalarian activityInorganic Chemistrychemistry.chemical_compoundAntimalarialsmedicineOrganometallic CompoundsMoietyRhodiumIridiumta116iridium complexesGroup 2 organometallic chemistrySchiff basechloroquine analogue ligands010405 organic chemistrypentamethylcyclopentadienyl-rhodium complexesChloroquine0104 chemical scienceschemistryDerivative (chemistry)medicine.drug
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CCDC 1426907: Experimental Crystal Structure Determination

2016

Related Article: Erik Ekengard, Kamlesh Kumar, Thibault Fogeron, Carmen de Kock, Peter J. Smith, Matti Haukka, Magda Monari, Ebbe Nordlander|2016|Dalton Trans.|45|3905|doi:10.1039/C5DT03739E

Space GroupCrystallographyCrystal System(eta5-pentamethylcyclopentadienyl)-(N-(7-chloroquinolin-4-yl)-N'-(pyridin-2-ylmethylene)ethane-12-diamine)-chloro-iridium(iii) chloride trihydrateCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1426908: Experimental Crystal Structure Determination

2016

Related Article: Erik Ekengard, Kamlesh Kumar, Thibault Fogeron, Carmen de Kock, Peter J. Smith, Matti Haukka, Magda Monari, Ebbe Nordlander|2016|Dalton Trans.|45|3905|doi:10.1039/C5DT03739E

Space GroupCrystallographyCrystal SystemCrystal Structure(eta5-pentamethylcyclopentadienyl)-(4-chloro-2-(((2-((7-chloroquinolin-4-yl)amino)ethyl)imino)methyl)phenolato)-chloro-rhodium(iii) dichloromethane solvateCell ParametersExperimental 3D Coordinates
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CCDC 1426906: Experimental Crystal Structure Determination

2016

Related Article: Erik Ekengard, Kamlesh Kumar, Thibault Fogeron, Carmen de Kock, Peter J. Smith, Matti Haukka, Magda Monari, Ebbe Nordlander|2016|Dalton Trans.|45|3905|doi:10.1039/C5DT03739E

(eta5-pentamethylcyclopentadienyl)-(N-(7-chloroquinolin-4-yl)-N'-(pyridin-2-ylmethyl)ethane-12-diamine)-chloro-rhodium(iii) chloride dichloromethane solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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