0000000000764769

AUTHOR

M. Santarelli

showing 4 related works from this author

CHCH10 mutations in an Italian cohort of familial and sporadic amyotrophic lateral sclerosis patients

2015

Mutations in CHCHD10 have recently been described as a cause of frontotemporal dementia (FTD) comorbid with amyotrophic lateral sclerosis (ALS). The aim of this study was to assess the frequency and clinical characteristics of CHCHD10 mutations in Italian patients diagnosed with familial (n= 64) and apparently sporadic ALS (n= 224). Three apparently sporadic patients were found to carry c.100C>T (p.Pro34Ser) heterozygous variant in the exon 2 of CHCHD10. This mutation had been previously described in 2 unrelated French patients with FTD-ALS. However, our patients had a typical ALS, without evidence of FTD, cerebellar or extrapyramidal signs, or sensorineural deficits. We confirm that CHC…

MaleAgingPediatricsmedicine.medical_specialtyPathologyAmyotrophic lateral sclerosis; CHCHD10; Familial; Sporadic; Aged; Amyotrophic Lateral Sclerosis; Cohort Studies; Female; Frontotemporal Dementia; Genetic Predisposition to Disease; Humans; Italy; Male; Middle Aged; Mitochondrial Proteins; Genetic Association Studies; MutationGenetic Association StudieDiseaseSettore MED/03 - GENETICA MEDICAmedicine.disease_causeCohort StudiesMitochondrial ProteinsExonFamilialmental disordersmedicineHumansMitochondrial ProteinDementiaGenetic Predisposition to DiseaseAmyotrophic lateral sclerosisAmyotrophic lateral sclerosis; CHCHD10; Familial; Sporadic; Aged; Amyotrophic Lateral Sclerosis; Cohort Studies; Female; Frontotemporal Dementia; Genetic Predisposition to Disease; Humans; Italy; Male; Middle Aged; Mitochondrial Proteins; Genetic Association Studies; Mutation; Neurology (clinical); Neuroscience (all); Aging; Developmental Biology; Geriatrics and GerontologyGenetic Association StudiesAmyotrophic lateral sclerosiAgedMutationNeuroscience (all)business.industryGeneral NeuroscienceMiddle AgedAmyotrophic lateral sclerosisSporadicmedicine.disease3. Good healthAmyotrophic lateral sclerosis; CHCHD10; Familial; SporadicCHCHD10ItalyFrontotemporal DementiaMutationCohortFemaleNeurology (clinical)Cohort StudieGeriatrics and GerontologybusinessHumanDevelopmental BiologyFrontotemporal dementiaCohort studyNeurobiology of Aging
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Surgeons' fear of getting infected by COVID19: A global survey

2020

During the last three months, COVID- 19 pandemic had led to a serious backlog of operations globally, and plans for restarting operation are imperative. Recommendations for surgical activities were studied, aiming to protect the surgical staff from being infected. In the meantime, it is also important to give attention to the surgeon’s personal feeling during work. We conducted a survey to investigate global surgi- cal practices during the COVID-19 pandemic, and the surgeon’s personal feeling was also investigated in the sur- vey. In this special letter, we performed multivariate analysis to explore factors that associated with surgeon’s fear of getting infected by COVID-19.

Surgery COVID-19medicine.medical_specialty2019-20 coronavirus outbreakInfectious Disease Transmission Patient-to-Professionalsurvey covid19Coronavirus disease 2019 (COVID-19)Attitude of Health PersonnelSettore MED/18 - CHIRURGIA GENERALESevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Infectious Disease TransmissionCOVID-19. Global surgery.MEDLINEGlobal HealthNOPatient-to-ProfessionalTumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]Surveys and QuestionnairesCorrespondencemedicineGlobal healthInfection controlHumansGeneralPersonal protective equipmentPersonal Protective EquipmentLS7_4SurgeonsInfection Controlcovid-19; pandemic; surgerySARS-CoV-2business.industrypandemicVaccinationCOVID-19covidFearSettore MED/18Occupational DiseasesCOVID-19; Global Health; Humans; Infection Control; Occupational Diseases; Personal Protective Equipment; Surgeons; Surveys and Questionnaires; Attitude of Health Personnel; Fear; Infectious Disease Transmission Patient-to-ProfessionalSurgeon - infection - COVID19 - surveyFamily medicineSurgerybusiness
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Changes in surgicaL behaviOrs dUring the CoviD-19 pandemic. The SICE CLOUD19 Study

2021

Abstract Background The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted the surgical community. Recommendations have been published to manage patients needing surgery during the COVID-19 pandemic. This survey, under the aegis of the Italian Society of Endoscopic Surgery, aims to analyze how Italian surgeons have changed their practice during the pandemic. Methods The authors designed an online survey that was circulated for completion to the Italian departments of general surgery registered in the Italian Ministry of Health database in December 2020. Questions were divided into three sections: hospital organization, screening policies, and safety profile of…

Laparoscopic surgerySettore MED/18 - CHIRURGIA GENERALEmedicine.medical_treatmentlaparoscopyCOVID-19; Elective surgery; Emergency surgery; Laparoscopic surgery; SurveyOral HealthLaparoscopic surgerycross infection (MeSH)COVID-19; Elective surgery; Emergency surgery; Laparoscopic surgery; Survey.Surveys and QuestionnairesEpidemiologyPandemicInfection controlPractice Patterns Physicians'emergency surgeryLaparoscopySurveyhumansmedicine.diagnostic_testGeneral Commentarylaparoscopic surgeryinfection controlItalyEmergency surgeryphysicians'Original ArticleElective Surgical ProcedureHumanheating ventilation air conditioningmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)fallow periodelective surgical procedurespandemicsNOaerosol generating proceduresSurvey.COVID-19; elective surgery; emergency surgery; laparoscopic surgery; survey; COVID-19; elective surgical procedures; humans; infection control; Italy; laparoscopy; pandemics; practice patterns physicians'; SARS-CoV-2; surveys and questionnairesmedicinesurveyElective surgeryElective surgeryInfection ControlElective Surgical ProcedurePandemicbusiness.industrySARS-CoV-2General surgerySurvey; Laparoscopic surgery; COVID-19; Elective surgery; Emergency surgeryCOVID-19practice patternsSurgeryelective surgerysurveys and questionnairesLaparoscopySurgerybusiness
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Impact of asymptomatic COVID-19 patients in global surgical practice during the COVID-19 pandemic

2020

The rapid spread of COVID-19 has changed the global surgical care. Patients infected with COVID-19 may present without typical symptoms, and such asymptomatic patients may potentially trigger in-hospital outbreaks by transmitting the disease to health care providers and other hospitalized patients. Further, asymptomatic COVID-19 patients have worse postop- erative outcomes with an unexpectedly high morbidity and mortality, reaching 20⋅5 per cent deaths. However, we do not have objective global data on this issue. In an attempt to clarify the current global surgical practice under the COVID-19 pandemic particularly focusing on the preoperative screening of asymptomatic COVID-19 patients, we …

2019-20 coronavirus outbreakmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)covid-19 pandemic surgerySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Settore MED/18 - CHIRURGIA GENERALEMEDLINECOVID-19. Global surgery.AsymptomaticCOVID-19 Critical Pathways Cross Infection Cross-Sectional Studies Health Care Surveys Humans Pandemics Postoperative Complications SARS-CoV-2 Surgical Procedures Operative Asymptomatic InfectionsCOVID-19; Critical Pathways; Cross Infection; Cross-Sectional Studies; Health Care Surveys; Humans; Pandemics; Postoperative Complications; SARS-CoV-2; Surgical Procedures Operative; Asymptomatic InfectionsNOsurgeryTumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]Postoperative ComplicationsPandemicCorrespondencemedicineHumansPandemicsAsymptomatic InfectionsLS7_4COVIDCross InfectionSurgical ProceduresCritical pathwaysbusiness.industrySARS-CoV-2pandemicCOVID-19Surgical proceduresOperativeSettore MED/18covid 19 surgical practiceCOVID-19 - surgeryCross-Sectional StudiesSurgical Procedures OperativeHealth Care SurveysEmergency medicineCritical Pathwaysmedicine.symptombusiness
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