0000000000764784

AUTHOR

Frank Rinaldi

showing 2 related works from this author

Steroid-growth factor interaction in human prostate cancer. 1. Short-term effects of transforming growth factors on growth of human prostate cancer c…

1994

In order to better define potential mechanisms of growth regulation in human prostate cancer cells, we have compared biological responses (such as short-term response to both transforming growth factor alpha and beta; TFG alpha and TFG beta) in relation to hormone sensitivity of LNCaP, DU145, and PC3 cells. Androgen receptor (AR) and epidermal growth factor receptor (EGF-R) content of each cell line was also investigated. In addition, expression of EGF, TGF alpha, and TGF beta was evaluated through immunofluorescent staining. Growth of androgen non-responsive PC3 cells was stimulated by TGF alpha (about 35%) and inhibited by TGF beta (more than 50%), with respect to controls, after 48 h exp…

Malemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentClinical BiochemistryFluorescent Antibody Techniqueurologic and male genital diseasesBiochemistryProstate cancerEndocrinologyDU145Transforming Growth Factor betaInternal medicineLNCaPTumor Cells CulturedmedicineHumansReceptors Growth FactorEpidermal growth factor receptorMolecular BiologyPharmacologybiologyGrowth factorOrganic ChemistryProstatic NeoplasmsTransforming Growth Factor alphamedicine.diseaseAndrogen receptorEndocrinologyReceptors AndrogenCancer cellAndrogensbiology.proteinCell DivisionTransforming growth factorSteroids
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Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolit…

1990

1. (+)-Aeroplysinin-1, a naturally occurring tyrosine metabolite from the marine sponge Verongia aerophoba, was found to inhibit the phosphorylation of lipocortin-like proteins by a highly purified preparation of the epidermal growth factor (EGF) receptor-tyrosine protein kinase complex from MCF-7 breast carcinoma cells. 2. (+)-Aeroplysinin-1 blocked the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibited the ligand-induced endocytosis of the EGF receptor in vitro. 3. Treatment with aeroplysinin-1 in the concentration range at 0.25-0.5 microM resulted in a time- and dose-dependent total tumor cell death in vitro. 4. At a 10-fold higher concentration…

Protein kinase complexAcetonitrilesTime FactorsPhysiologyBlotting WesternBreast NeoplasmsBiologyBiochemistrySubstrate SpecificityMiceEpidermal growth factorCyclohexenesTumor Cells CulturedAnimalsHumansPhosphorylationTyrosineMolecular BiologyDose-Response Relationship DrugKinaseGeneral MedicineProtein-Tyrosine KinasesMolecular biologyPoriferaErbB ReceptorsBiochemistryCell cultureCancer cellPhosphorylationCalciumTyrosine kinaseCell DivisionComparative Biochemistry and Physiology Part B: Comparative Biochemistry
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