0000000000764801

AUTHOR

Frédéric Bellec

showing 3 related works from this author

Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (N…

2017

International audience; BackgroundWhether the route of early feeding affects outcomes of patients with severe critical illnesses is controversial. We hypothesised that outcomes were better with early first-line enteral nutrition than with early first-line parenteral nutrition.MethodsIn this randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2 trial) done at 44 French intensive-care units (ICUs), adults (18 years or older) receiving invasive mechanical ventilation and vasopressor support for shock were randomly assigned (1:1) to either parenteral nutrition or enteral nutrition, both targeting normocaloric goals (20–25 kcal/kg per day), within 24 h after intubatio…

AdultMaleParenteral NutritionPediatricsmedicine.medical_specialtyTime FactorsCritical CareSecondary infectionEnteral feedingClinical nutritionEnteral administrationlaw.invention03 medical and health sciencesEnteral Nutrition0302 clinical medicineRandomized controlled triallaw[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologyHumansVasoconstrictor AgentsMedicineCumulative incidenceHospital Mortality030212 general & internal medicineNutritional supportAgedAcute critical illnessbusiness.industryMalnutritionHazard ratioShock030208 emergency & critical care medicineGeneral MedicineLength of StayMiddle AgedInterim analysisRespiration ArtificialThe enteral route3. Good healthTreatment OutcomeParenteral nutritionFemalebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyThe Lancet
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Nephrotoxic drug burden among 1001 critically ill patients: impact on acute kidney injury.

2019

Abstract Background Nephrotoxic drug prescription may contribute to acute kidney injury (AKI) occurrence and worsening among critically ill patients and thus to associated morbidity and mortality. The objectives of this study were to describe nephrotoxic drug prescription in a large intensive-care unit cohort and, through a case–control study nested in the prospective cohort, to evaluate the link of nephrotoxic prescription burden with AKI. Results Six hundred and seventeen patients (62%) received at least one nephrotoxic drug, among which 303 (30%) received two or more. AKI was observed in 609 patients (61%). A total of 351 patients were considered as cases developing or worsening AKI a gi…

medicine.medical_specialtyIntensive-care units [MeSH]Critical Care and Intensive Care Medicine[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and NephrologyMESH: Vancomycin03 medical and health sciences0302 clinical medicineMESH: Kidney tubular necrosisRenal insufficiency [MeSH]Internal medicineAnesthesiologyMESH: Renal insufficiencymedicineMESH: Intensive-care unitsKidney tubular necrosisMESH: Diuretics030212 general & internal medicineMedical prescriptionSimplified Acute Physiology ScoreProspective cohort studyMESH: Acutebusiness.industryResearchAcute kidney injurylcsh:Medical emergencies. Critical care. Intensive care. First aidMESH: Aminoglycosides030208 emergency & critical care medicineOdds ratiolcsh:RC86-88.9[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciencesmedicine.diseaseVancomycin [MeSH][SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and NephrologyDiuretics [MeSH]3. Good health[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciencesContrast media [MeSH]CohortMESH: Contrast mediaAminoglycosides [MeSH]businessAcute [MeSH]Kidney diseaseAnnals of intensive care
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Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease

2021

OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need fo…

Malemedicine.medical_treatmentpulmonary complicationsRESPIRATORY-DISTRESS-SYNDROMECritical Care and Intensive Care MedicineCASE-FATALITY0302 clinical medicineRisk FactorsBrain Injuries TraumaticMulticenter Studies as TopicHospital MortalityProspective StudiesSimplified Acute Physiology ScoreStrokePOPULATIONSimplified Acute Physiology ScoreAge FactorsANEURYSMAL SUBARACHNOID HEMORRHAGEMiddle AgedHemorrhagic StrokeIntensive Care UnitsObservational Studies as TopicAnesthesiaBreathingFemalemedicine.symptomVentilator WeaningCohort studyAdultTRAUMATIC BRAIN-INJURYPressure support ventilationmechanical ventilationprognosis factorsACUTE LUNG INJURY03 medical and health sciencesmedicineHumansAgedIschemic StrokeMechanical ventilationNoninvasive Ventilationbusiness.industryMORTALITYneurologic patientsOrgan dysfunction030208 emergency & critical care medicineLength of Staymedicine.diseaseTRENDSRespiration Artificial030228 respiratory systemEtiologyNEUROCRITICAL CARENervous System DiseasesTracheotomybusinessCritical Care Medicine
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