0000000000765395
AUTHOR
Antonio Beltran
Targeting Neoepitopes to Treat Solid Malignancies: Immunosurgery
Successful outcome of immune checkpoint blockade in patients with solid cancers is in part associated with a high tumor mutational burden (TMB) and the recognition of private neoantigens by T-cells. The quality and quantity of target recognition is determined by the repertoire of ‘neoepitope’-specific T-cell receptors (TCRs) in tumor-infiltrating lymphocytes (TIL), or peripheral T-cells. Interferon gamma (IFN-γ), produced by T-cells and other immune cells, is essential for controlling proliferation of transformed cells, induction of apoptosis and enhancing human leukocyte antigen (HLA) expression, thereby increasing immunogenicity of cancer cells. TCR αβ-dependent therapies should account f…
Some problems about products of conjugacy classes in finite groups
[EN] We summarize several results about non-simplicity, solvability and normal structure of finite groups related to the number of conjugacy classes appearing in the product or the power of conjugacy classes. We also collect some problems that have only been partially solved.