0000000000765812

AUTHOR

Adam D. Abbs

showing 2 related works from this author

Human Immunodeficiency Virus Infection and Diverse Physical Health Outcomes: An Umbrella Review of Meta-analyses of Observational Studies.

2019

Abstract Background Our aim was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies and physical health outcomes associated with human immunodeficiency virus (HIV) but not acquired immunodeficiency syndrome. Methods We performed an umbrella review of observational studies. Evidence was graded as convincing, highly suggestive, suggestive, weak, or nonsignificant. Results From 3413 studies returned, 20 were included, covering 55 health outcomes. Median number of participants was 18 743 (range 403–225 000 000). Overall, 45 (81.8%) of the 55 unique outcomes reported nominally significant summary results (P < .05). O…

Microbiology (medical)medicine.medical_specialtyPopulationcomorbidHIV InfectionsDisease03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineAcquired immunodeficiency syndrome (AIDS)Meta-Analysis as TopicPre-EclampsiaPregnancyInternal medicineMedicineHumanshealth outcomes030212 general & internal medicineeducationArticles and CommentariesCOPDeducation.field_of_studyhuman immunodeficiency virusumbrella reviewbusiness.industryhuman immunodeficiency viruPublic healthIncidence (epidemiology)IncidenceAn Umbrella Review of Meta-analyses of Observational Studies.- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019 [Grabovac I. Veronese N. Stefanac S. Haider S. Jackson S. Koyanagi A. Meilinger M. Stubbs B. Firth J. Soysal P. et al. -Human Immunodeficiency Virus Infection and Diverse Physical Health Outcomes]HIVmedicine.diseaseComorbidityObservational Studies as TopicInfectious DiseasesCross-Sectional StudiesAcademicSubjects/MED00290health outcomeFemalebusiness030217 neurology & neurosurgeryCohort studySystematic Reviews as TopicClinical infectious diseases : an official publication of the Infectious Diseases Society of America
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Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.

2019

The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. To evaluate the credibility of the identified evidence, we assessed also heterogeneity, evidence for small-study effect and evidence for excess significance bias. Twenty-one…

0301 basic medicineAgingPopulationDiseaseBiochemistry03 medical and health sciencesUmbrella review0302 clinical medicineAlzheimer DiseaseStomach NeoplasmsDiabetes MellitusMedicineHumanseducationObservational studiesMolecular Biologyeducation.field_of_studyTelomere lengthbusiness.industryIncidence (epidemiology)IncidenceEvidence-based medicineTelomereConfidence intervalObservational Studies as Topic030104 developmental biologySystematic reviewTreatment OutcomeNeurologyTelomere length; Umbrella review; Observational studiesRelative riskCase-Control Studies*Telomere length*Observational studiesObservational studybusiness*Umbrella review030217 neurology & neurosurgeryBiotechnologyDemography
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