0000000000766873

AUTHOR

Javier De La Fuente

showing 3 related works from this author

Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial …

2015

BACKGROUND: Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagon-like peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated.METHODS: ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallel-group, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population …

Malemedicine.medical_specialtyAcute coronary syndromePopulationLIXisenatide610 Medicine & healthHypoglycemiaPlacebop38 Mitogen-Activated Protein Kinases11171 Cardiocentro Ticino2705 Cardiology and Cardiovascular Medicinelaw.inventionSettore MED/13 - EndocrinologiaAcute Coronary Syndrome; Aged; Cardiovascular Diseases; Double-Blind Method; Female; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; Peptides; Placebos; Protein Kinase Inhibitors; Research Design; p38 Mitogen-Activated Protein Kinases; Cardiology and Cardiovascular MedicinePlacebosLixisenatidechemistry.chemical_compoundRandomized controlled trialDouble-Blind MethodlawGlucagon-Like Peptide 1Internal medicineJournal ArticlemedicineHumansComparative StudyMyocardial infarctionAcute Coronary SyndromeeducationProtein Kinase InhibitorsAgededucation.field_of_studybusiness.industryUnstable anginaResearch Support Non-U.S. Gov'tta3121Middle Agedmedicine.diseaseSurgeryMulticenter StudychemistryCardiovascular DiseasesResearch DesignRandomized Controlled TrialCardiologyFemaleCardiology and Cardiovascular MedicinebusinessPeptides
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Re: The Clinical Impact of Bacteremia on Outcomes in Elderly Patients with Pyelonephritis or Urinary Sepsis: A Prospective Multicenter Study

2018

Background Bacteremia is common in severe urinary infections, but its influence on the outcomes is not well established. The aim of this study was to assess the association of bacteremia with outcomes in elderly patients admitted to hospital with pyelonephritis or urinary sepsis. Methods This prospective muticenter observational study was conducted at 5 Spanish hospitals. All patients aged >65 years with pyelonephritis or urinary sepsis admitted to the departments of internal medicine and with urine and blood cultures obtained at admission to hospital were eligible. Transfer to ICU, length of hospital stay, hospital mortality and all cause 30-day mortality in bacteremic and non-bacteremic g…

Bacterial DiseasesMaleMultivariate analysisPhysiologylcsh:MedicineBacteremiaUrineUrinePathology and Laboratory MedicineElderly0302 clinical medicineMedicine and Health Sciences030212 general & internal medicineProspective Studieslcsh:ScienceProspective cohort studyAged 80 and overMultidisciplinaryPyelonephritisHospitalsBody FluidsInfectious DiseasesBloodCohortUrinary Tract InfectionsFemaleAnatomyResearch Articlemedicine.medical_specialtyUrologyUrinary systemMEDLINESepsis03 medical and health sciencesSigns and SymptomsDiagnostic MedicineSepsisInternal medicinemedicineHumansAgedSeptic shockbusiness.industrylcsh:RBiology and Life Sciencesmedicine.diseaseHealth Care030228 respiratory systemMulticenter studyHealth Care FacilitiesGeriatricsAge GroupsBacteremiaPeople and PlacesPopulation Groupingslcsh:QbusinessJournal of Urology
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Inadequate empirical antimicrobial treatment in older people with bacteremic urinary tract infection who reside in nursing homes: A multicenter prosp…

2019

AIM The aim of the study was to determine the rate of inadequate empirical antimicrobial treatment in older nursing home residents with bacteremic urinary tract infection and its influence on prognosis. METHODS We carried out a multicentric prospective observational study in five Spanish hospitals. Patients aged >65 years with pyelonephritis or urinary sepsis with bacteremia were included. Clinical characteristics, the percentage of inadequate empirical antibiotic treatment, length of hospital stay and mortality were evaluated. RESULTS A total of 181 patients, 54.7% women, were included in the study, and 35.9% of the patients came from nursing homes. These patients had higher percentages of…

Malemedicine.medical_specialtyMultivariate analysismedicine.drug_classUrinary systemAntibioticsBacteremiaInappropriate PrescribingSepsisInternal medicinemedicineHomes for the AgedHumansProspective StudiesAgedAged 80 and overbusiness.industrymedicine.diseaseAntimicrobialAnti-Bacterial AgentsNursing HomesSpainBacteremiaUrinary Tract InfectionsObservational studyFemaleNursing homesbusinessGeriatricsgerontology internationalReferences
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