Acremines A-F, novel secondary metabolites produced by an endophytic strain of Acremonium sp., isolated in grape leaves infected by Plasmopara viticola

Six novel metabolites, acremines A–F have been isolated from agar cultures of a strain of Acremonium sp. Their structures and stereochemistry were elucidated using a combination of 13C and 1H homo and heteronuclear 2D NMR experiments and X-ray analysis. Acremines A–D inhibited the germination of sporangia of Plasmopara viticola.