Real-time Patterns of Behavior Following Nociceptive Stimulation in Rats

The hot-plate test is employed, in rodents, to assess the analgesic properties of drugs. The surface where the animal is placed is normally maintained at a constant temperature around 50°C or 55°C. For this reason rat’s behavior, once placed on the heated surface, can be observed only for few seconds, and a necessary interruption occurs following an a priori-established cut-off to avoid tissue injuries. Such a narrow time window dampened the assessment of fine behavioral characteristics such as the temporal structure of behavior. In the present paper we demonstrate the possibility to apply a refined multivariate approach, known as T-pattern analysis (TPA), to describe the temporal character…

INVOLVEMENT OF NITRIC OXIDE IN MAXIMAL DENTATE GYRUS ACTIVATION IN THE RAT

Crucial Role of the 5-HT2C Receptor in Regulating the Activity of the Substantia Nigra Pars Reticulata Neurons: An Electrophysiological Study in Rats. 5th Forum of European Neuroscience - Vienna

Activation of 5-HT2C receptors stimulates GABA-ergic neurons of the rat substantia nigra pars reticulata: an in vivo microiontophoretic study.

THE BASAL GANGLIA PATHOPHYSIOLOGY: RECENT ADVANCES

Serotonin-Dopamine Interaction: Experimental and Therapeutic Evidence

This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson’s disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners an…

SPECIAL ISSUE "NEURODEGENERATIVE DISORDERS: FROM MOLECULES TO MAN"

Neurodegenerative Disorders: From Molecules to Man. Part II