0000000000770724
AUTHOR
Gerhard Schuler
Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived dendritic cells.
Abstract Dendritic cell (DC) vaccination, albeit still in an early stage, is a promising strategy to induce immunity to cancer. We explored whether DC can expand Ag-specific CD8+ T cells even in far-advanced stage IV melanoma patients. We found that three to five biweekly vaccinations of mature, monocyte-derived DC (three vaccinations of 6 × 106 s.c. followed by two i.v. ones of 6 and 12 × 106, respectively) pulsed with Mage-3A2.1 tumor and influenza matrix A2.1-positive control peptides as well as the recall Ag tetanus toxoid (in three of eight patients) generated in all eight patients Ag-specific effector CD8+ T cells that were detectable in blood directly ex vivo. This is the first time …
On versus off-hour care of patients with acute coronary syndrome and persistent ST-segment elevation in certified German chest pain units
BACKGROUND Regional healthcare projects improve the off-hour care of patients with acute coronary syndromes and persistent ST-segment elevation myocardial infarction (STEMI). To analyse differences in quality of care between on and off-hour care of STEMI patients admitted to certified German chest pain units. METHODS A total of 1107 STEMI patients from the German chest pain unit registry were enrolled. Analyses comprised critical time intervals (symptoms to first medical contact (FMC), FMC to admission, symptoms to admission, symptoms to balloon, FMC to balloon, door to balloon times) and major adverse cardiac and cerebrovascular events at follow-up. RESULTS 54.8% of patients were admitted …
Complete amplitude and cross section structure of one-loop contributions toe + e ??q $$\bar q$$ g
We calculate theO(α 2 ) one-loop contributions to the seven (inn≠4) independent invariant amplitudes describinge + e −→q $$\bar q$$ g in massless QCD. After folding with theO(α 1/2 ) Born term contribution we obtain the nine independentO(α 2 ) structure functions that describe the parity-conserving and parity-violating contributions toe + e −→q $$\bar q$$ g. We use dimensional regularization to control infrared and ultraviolet divergencies.