0000000000771435

AUTHOR

Z Khaleeli

showing 2 related works from this author

Grey matter damage and overall cognitive impairment in primary progressive multiple sclerosis

2011

Objectives: To identify associations between cognitive impairment and imaging measures in a cross-sectional study of patients with primary progressive multiple sclerosis (PPMS). Methods: Neuropsychological tests were administered to 27 patients with PPMS and 31 controls. Patients underwent brain conventional magnetic resonance imaging (MRI) sequences, volumetric scans and magnetization transfer (MT) imaging; MT ratio (MTR) parameters, grey matter (GM) and normal-appearing white matter (NAWM) volumes, and WM T2 lesion load (T2LL) were obtained. In patients, multiple linear regression models identified the imaging measure associated with the abnormal cognitive tests independently from the ot…

AdultMalemedicine.medical_specialtyprimary progressive multiple sclerosisAudiologyGrey matterNeuropsychological TestsWhite matterExecutive FunctionCognitionMemoryPredictive Value of TestsLondonmedicineHumansAttentionEffects of sleep deprivation on cognitive performanceAgedChi-Square Distributionmedicine.diagnostic_testSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaVerbal BehaviorMultiple sclerosisNeuropsychologyBrainCognitionMagnetic resonance imagingMiddle AgedMultiple Sclerosis Chronic Progressivemedicine.diseaseMagnetic Resonance ImagingCognitive testmedicine.anatomical_structureCross-Sectional StudiesNeurologyCase-Control StudiesLinear ModelsFemaleNeurology (clinical)PsychologyCognition DisordersNeuroscience
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Early imaging predicts later cognitive impairment in primary progressive multiple sclerosis

2010

Background: Cognitive impairment in primary progressive multiple sclerosis (PPMS) is common and correlates modestly with contemporary lesion burden and brain volume. Using a cohort/case control methodology, we explore the ability of MRI abnormalities, including those in the normal-appearing brain tissue, to predict future cognitive dysfunction in PPMS. Methods: Thirty-one patients recruited into a longitudinal study within 5 years of onset of PPMS were assessed neuropsychologically on average 5.5 years later along with 31 matched healthy controls. MRI data obtained at entry into the study (lesion metrics, brain volumes, magnetization transfer ratio histogram metrics, and magnetic resonance …

AdultMalemedicine.medical_specialtyMagnetic Resonance SpectroscopyTime Factorsprimary progressive multiple sclerosisNeuropsychological TestsAudiologyNerve Fibers MyelinatedLesionWhite matterCentral nervous system diseasemedicineHumansLongitudinal StudiesAgedNerve Fibers UnmyelinatedMultiple sclerosisCognitive disorderBrainCognitionOrgan SizeMiddle AgedMultiple Sclerosis Chronic Progressivemedicine.diseaseMagnetic Resonance Imagingmedicine.anatomical_structureCase-Control StudiesBrain sizeFemaleNeurology (clinical)Verbal memorymedicine.symptomCognition DisordersPsychologyNeuroscienceFollow-Up StudiesNeurology
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