0000000000771646

AUTHOR

Laura Sensi

showing 3 related works from this author

Safety of sublingual immunotherapy started during the pollen season

2009

Sublingual immunotherapy (SLIT) is safer than subcutaneous immunotherapy (SCIT) and this has lead to the reconsideration of the use of ultra-rush schedules for SLIT. The aim of this study was to assess the safety of ultra-rush SLIT in pollen-allergic children according to different timing of administration in relation to the pollen season.In total, 34 children with pollen-induced rhinitis and 36 with pollen-induced asthma and rhinitis, were enrolled and assigned to three study groups: group 1 (n = 17 patients): conventional pre-seasonal-SLIT treatment; group 2 (n = 23 patients), seasonal SLIT ended before the pollen seasonal peak; group 3 (n = 30 patients), SLIT began after the pollen seaso…

Study groupsmedicine.medical_specialtyPediatricsAdolescentAdministration SublingualPollen Allergymedicine.disease_causePollenotorhinolaryngologic diseasesmedicineSubcutaneous immunotherapyHumansRhinitis Allergic Seasonal; Humans; Allergens; Asthma; Desensitization Immunologic; Child; Adolescent; Administration Sublingual; Pollen; Child PreschoolSublingual immunotherapyChildAsthmaPollen seasonbusiness.industryAllergenRhinitis Allergic Seasonalfood and beveragesGeneral MedicineAllergensmedicine.diseaseSlitAsthmaeye diseasesSurgerySLIT Ultra-RUSHDesensitization ImmunologicChild PreschoolPollensense organsbusinessHuman
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Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years

2005

Background The minimum age to start specific immunotherapy with inhalant allergens in children has not been clearly established, and position papers discourage its use in children younger than 5 years. Objective To assess the safety of high-dose sublingual-swallow immunotherapy (SLIT) in a group of children younger than 5 years. Methods Sixty-five children (51 boys and 14 girls; age range, 38-80 months; mean ± SD age, 60 ± 10 years; median age, 60 months) were included in this observational study. They were treated with SLIT with a build-up phase of 11 days, culminating in a top dose of 300 IR (index of reactivity) and a maintenance phase of 300 IR 3 times a week. The allergens used were ho…

MalePulmonary and Respiratory MedicinePediatricsmedicine.medical_specialtyParietariaImmunologyAdministration SublingualSublingual administrationImmunopathologyAge Factors; Conjunctivitis Allergic; Humans; Allergens; Asthma; Rhinitis; Child; Desensitization Immunologic; Administration Sublingual; Male; Female; Child PreschoolHumansImmunology and AllergyMedicineAge FactorChildRhinitiRhinitisConjunctivitis Allergicbiologybusiness.industryCumulative doseAllergenAge FactorsAllergensbiology.organism_classificationAsthmaDiscontinuationClinical trialEl NiñoDesensitization ImmunologicChild PreschoolFemaleObservational studybusinessHumanAnnals of Allergy, Asthma & Immunology
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Bone metabolism in children with asthma treated with nebulized flunisolide: a multicenter italian study

1998

Abstract This multicenter, parallel-group, open-label, randomized study was conducted in prepubertal children with mild asthma to investigate the efficacy and influence on bone and collagen turnover of a daily regimen of flunisolide 1200 μg alone (group A, n=14), flunisolide 600 μg in combination with sodium cromoglycate (SCG) 60 mg (group B, n=15), or SCG 60 mg alone (group C, n=15) for 4 months. All medications were administered by means of a jet nebulizer using a mouthpiece. Serum osteocalcin (OC), bone alkaline phosphate (B-ALP), and procollagen type I carboxyterminal propeptide (PICP) were measured as markers of bone formation, and type I collagen telopeptide (ICTP) was measured as a m…

Pharmacologymedicine.medical_specialtyCromoglicic acidbusiness.industrymedicine.drug_classmedicine.diseaseGastroenterologyBone resorptionBone remodelingRegimenEndocrinologyN-terminal telopeptideInternal medicinemedicineFlunisolideCorticosteroidPharmacology (medical)businessAsthmamedicine.drugCurrent Therapeutic Research
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