0000000000771925

AUTHOR

Silvia Tejada

showing 2 related works from this author

Targeting epigenetics in cancer: therapeutic potential of flavonoids

2021

Irrespective of sex and age, cancer is the leading cause of mortality around the globe. Therapeutic incompliance, unwanted effects, and economic burdens imparted by cancer treatments, are primary health challenges. The heritable features in gene expression that are propagated through cell division and contribute to cellular identity without a change in DNA sequence are considered epigenetic characteristics and agents that could interfere with these features and are regarded as potential therapeutic targets. The genetic modification accounts for the recurrence and uncontrolled changes in the physiology of cancer cells. This review focuses on plant-derived flavonoids as a therapeutic tool for…

FlavonolsAnticancer; cancer therapy; epigenetic; flavonoids; Diet; Epigenesis Genetic; Flavonols; Humans; Flavonoids; NeoplasmsBioinformaticsFlavonesIndustrial and Manufacturing EngineeringEpigenesis Geneticchemistry.chemical_compoundFlavonolsGeneticNeoplasmsmedicineHumansEpigeneticsFlavonoidschemistry.chemical_classificationbusiness.industryfood and beveragesCancerGeneral MedicineIsoflavonesmedicine.diseaseDietClinical trialAnticancerchemistryCancer cellcancer therapyDelphinidinbusinessAnticancer; cancer therapy; epigenetic; flavonoidsepigeneticEpigenesisFood ScienceCritical Reviews in Food Science and Nutrition
researchProduct

Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway

2020

Cardiovascular diseases comprise of non-communicable disorders that involve the heart and/or blood vessels and have become the leading cause of death worldwide with increased prevalence by age. mTOR is a serine/threonine-specific protein kinase which plays a central role in many physiological processes including cardiovascular diseases, and also integrates various proliferative signals, nutrient and energy abundance and stressful situations. mTOR also acts as central regulator during chronic stress, mitochondrial dysfunction and deregulated autophagy which are associated with senescence. Under oxidative stress, mTOR has been reported to exert protective effects regulating apoptosis and auto…

0301 basic medicineSenescenceRegulatorDiseasemedicine.disease_causeNatural product03 medical and health sciences0302 clinical medicineAnimalsHumansMedicineChronic stressProtein kinase API3K/AKT/mTOR pathwayPharmacologybusiness.industryTOR Serine-Threonine KinasesAutophagyPolyphenols030104 developmental biologyCardiovascular Diseases030220 oncology & carcinogenesismTORCancer researchTranscription factorbusinessOxidative stressSignal TransductionPharmacological Research
researchProduct