Bimodal tracers synthesis for medical imaging PET/MRI

2015

Today physicians can use a wide variety of medical imaging techniques to establish early and accurate diagnosis. Nevertheless, each modality has its own advantages and drawbacks. This is why bi- or multimodality approach seems interesting. Among them, PET/MRI combination seems very promising because it can bring complementary informations. It is therefore necessary to inject to patients tracers specific to each imaging modality. This work described the synthesis of molecular platforms for MRI and PET imaging, according to 2 different strategies. The first one consisted in the synthesis of a DO3A macrocycle allowing the chelation of both gadolinium for MRI and gallium 68 for PET. The aim her…