0000000000773565
AUTHOR
Janina Von Hilchen
Genetic regulation and function of epidermal growth factor receptor signalling in patterning of the embryonicDrosophilabrain
The specification of distinct neural cell types in central nervous system development crucially depends on positional cues conferred to neural stem cells in the neuroectoderm. Here, we investigate the regulation and function of the epidermal growth factor receptor (EGFR) signalling pathway in early development of theDrosophilabrain. We find that localized EGFR signalling in the brain neuroectoderm relies on a neuromere-specific deployment of activating (Spitz, Vein) and inhibiting (Argos) ligands. Activated EGFR controls the spatially restricted expression of all dorsoventral (DV) patterning genes in a gene- and neuromere-specific manner. Further, we reveal a novel role of DV genes—ventral …
Genetic regulation and function of EGFR signalling in patterning of the embryonic Drosophila brain by Urbach et al - Supplemental Material from Genetic regulation and function of epidermal growth factor receptor signalling in patterning of the embryonic Drosophila brain
File includes Supplemental Material and Methods, and Supplemental Figures S1-5