0000000000775308

AUTHOR

Damiana Téllez-martínez

0000-0001-6957-094x

showing 1 related works from this author

Foxp3 Silencing with Antisense Oligonucleotide Improves Immunogenicity of an Adjuvanted Recombinant Vaccine against Sporothrix schenckii

2021

Made available in DSpace on 2021-06-25T10:56:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: In recent years, there has been great interest in developing molecular adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor pathways with inhibitory effects on regulatory T cells (Tregs) to improve immunogenicity and vaccine efficacy. We aim to evaluate the immunostimulating effect of 2′OMe phosphorothioated Foxp3-targeted ASO in an antifungal adjuvanted recombinant vaccine. Methods: The uptake kinetics of Foxp3 ASO, its cyto-toxicity and its ability to deplete Tregs were evaluated in…

Farmacologiamedicine.medical_treatmentÀcids nucleicschemical and pharmacologic phenomenaCatalysisregulatory T cellslaw.inventionInorganic Chemistrylcsh:Chemistryvaccine immunogenicityImmune systemlawantisensense oligonucleotidemedicineVacunacióPhysical and Theoretical ChemistryMolecular Biologylcsh:QH301-705.5SpectroscopySporothrix schenckiibiologybusiness.industryImmunogenicityOrganic ChemistryAntibody titerGeneral MedicineFongs patògensVaccine efficacyComputer Science ApplicationsVaccinationlcsh:Biology (General)lcsh:QD1-999Foxp3ImmunologyRecombinant DNAbiology.proteinAntibody<i>Sporothrix schenckii</i>businessAdjuvantInternational Journal of Molecular Sciences
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