0000000000776544
AUTHOR
Werner Muller
Innate Sensing by Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
MyD88, an adaptor molecule downstream of innate pathways, plays a significant tumor-promoting role in sporadic intestinal carcinogenesis, which is dependent on its function in the stroma. Here, we show that deletion of MyD88 in intestinal mesenchymal cells (IMCs) significantly reduces Apc-mediated intestinal tumorigenesis. This phenotype is associated with decreased epithelial cell proliferation, altered inflammatory and tumorigenic immune cell infiltration, and modified gene expression similar to complete MyD88 knockout mice. Genetic deletion of TLR4, but not IL1R, in IMCs led to altered molecular profiles and reduction of intestinal tumors similar to the MyD88 deficiency. Ex vivo analysis…
Der frühmesolithische Abri Berglibalm im Bisistal, Gemeinde Muotathal SZ
International audience
The mesolithic Berglibalm Rock Shelter (Muotathal, Ct. Schwyz/ CH)
International audience
Walter Imhof, Werner Müller und Werner H. Schoch, Das Flözerbändli- ein kunstvolles Jagdlager aus der Steinzeit
International audience