0000000000776802

AUTHOR

M. I. Martínez‐mir

showing 2 related works from this author

Histamine inhibits spontaneous activity of the uterus of the progesterone-treated rat

1993

Pharmacologymedicine.medical_specialtyGeneral NeuroscienceUterusHistamine H1 receptorBiologychemistry.chemical_compoundmedicine.anatomical_structureEndocrinologychemistryHistamine H2 receptorIn uteroInternal medicinemedicineCatecholamineLiberationmedicine.symptomHistamineMuscle contractionmedicine.drugJournal of Autonomic Pharmacology
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Study on the histamine-like activity of guanfacine

1990

Abstract The effects of guanfacine have been studied on guinea-pig isolated atria and diethylstilboestrol-treated rat isolated uterus to determine whether it possesses histamine-like activity. Guanfacine produced a concentration-dependent negative chronotropic effect which was not modified by ranitidine (0.1 μM). In rat isolated uterus contracted by KCl, clonidine (5–5000 μM) produced concentration-dependent relaxation which was blocked by ranitidine (0.1 μM), but guanfacine only produced relaxation at high concentrations (100–1000 μM), and this was not affected by ranitidine (0.1 μM). It is concluded that guanfacine, unlike clonidine, does not produce effects due to activation of H2-recept…

Chronotropicmedicine.medical_specialtyGuinea PigsUterusPharmaceutical SciencePharmacologyClonidinePotassium ChlorideGuinea pigRanitidineUterine Contractionchemistry.chemical_compoundInternal medicinemedicineAnimalsHeart AtriaDiethylstilbestrolPharmacologyDose-Response Relationship Drugbusiness.industryRats Inbred StrainsMyocardial ContractionGuanfacineRatsGuanfacineClonidineEndocrinologymedicine.anatomical_structureMechanism of actionchemistryFemalemedicine.symptombusinessAdrenergic alpha-AgonistsHistaminemedicine.drugJournal of Pharmacy and Pharmacology
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