0000000000780030
AUTHOR
N. Taylor
Overview of the DEMO staged design approach in Europe
This paper describes the status of the pre-conceptual design activities in Europe to advance the technical basis of the design of a DEMOnstration Fusion Power Plant (DEMO) to come in operation around the middle of this century with the main aims of demonstrating the production of few hundred MWs of net electricity, the feasibility of operation with a closed-tritium fuel cycle, and maintenance systems capable of achieving adequate plant availability. This is expected to benefit as much as possible from the ITER experience, in terms of design, licensing, and construction. Emphasis is on an integrated design approach, based on system engineering, which provides a clear path for urgent R&D …
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis
Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds…