0000000000784643

AUTHOR

P Esposito

showing 2 related works from this author

Retrospective, observational, multicentre study on an Italian population affected by chronic hepatitis C who failed to clear HCV-RNA after the combin…

2010

There is a lack of information on the characteristics of patients with chronic hepatitis C virus infection (HCV) who fail to respond to antiviral treatment. We studied HCV-positive subjects with chronic liver diseases treated with pegylated-interferon (PEG-IFN) and ribavirin (RBV) who failed to clear HCV in routine clinical practice. A total of 2150 consecutive adult patients treated with PEG-IFN plus RBV therapy in 46 Italian centres between 1 July 2004, and 30 June 2005, were studied. Of the 2150 patients, 923 (42.9%) (M/F 585/335, mean age 54.8 years) failed to achieve a serum HCV-RNA clearance. Of these 923 patients, 429 (46.5%) were nonresponders, 298 (32.3%) relapsers, 168 (18.2%) dro…

AdultMalenon-responders.relapserGenotypebody mass index; cirrhosis; hepatitis c virus; nonresponder; pegylated-interferon; relapserInfectious Diseasebody mass indexHepacivirusvirusInterferon alpha-2Antiviral AgentsPolyethylene GlycolPolyethylene GlycolsMedication Adherencebody mass index; cirrhosis; hepatitis C; virus; nonresponder; pegylated-interferon; relapserRisk FactorsRetrospective StudienonresponderVirologyRibavirinHumansAge FactorTreatment FailureRetrospective StudiesAgedAntiviral AgentSettore MED/12 - GastroenterologiaHCV; Antiviral therapy; Body mass index; Cirrhosis; Hepatitis C virus; Nonresponder; Pegylated-interferon; RelapserCirrhosiHepaciviruHepatologyRisk FactorcirrhosisAge FactorsInterferon-alphahepatitis c virusHepatitis C ChronicMiddle AgedRecombinant ProteinRecombinant ProteinsItalyRNA ViralFemalehepatitis Cpegylated-interferonHepatitis C viruHuman
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The LOFT mission concept: a status update

2016

The Large Observatory For x-ray Timing (LOFT) is a mission concept which was proposed to ESA as M3 and M4 candidate in the framework of the Cosmic Vision 2015-2025 program. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument and the uniquely large field of view of its wide field monitor, LOFT will be able to study the behaviour of matter in extreme conditions such as the strong gravitational field in the innermost regions close to black holes and neutron stars and the supra-nuclear densities in the interiors of neutron stars. The science payload is based on a Large Area Detector (LAD, >8m2 effective area, 2-30 keV, 240 eV spectral resolut…

X-ray timing[ SDU.ASTR.GA ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA]Field of viewAstrophysics01 natural scienceslaw.inventionlawObservatorytiming010303 astronomy & astrophysicsQBPhysicsmicrochannel plates. PROPORTIONAL COUNTER ARRAYCALIBRATIONX-ray astronomyElectronic Optical and Magnetic MaterialApplied MathematicsAstrophysics::Instrumentation and Methods for AstrophysicsComputer Science Applications1707 Computer Vision and Pattern RecognitionX-ray detectorsCondensed Matter Physicscompact objectsX-ray spectroscopy[SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA]spectroscopyCosmic Vision[ INFO ] Computer Science [cs]Silicon detectorAstrophysics::High Energy Astrophysical PhenomenaCondensed Matter PhysicTelescopeX-rayX-ray astronomySilicon detectors; spectroscopy; timing; X-ray astronomy; Electronic Optical and Magnetic Materials; Condensed Matter Physics; Applied Mathematics; Electrical and Electronic EngineeringSettore FIS/05 - Astronomia e Astrofisica0103 physical sciencesElectronic[INFO]Computer Science [cs]Optical and Magnetic MaterialsSpectral resolutionElectrical and Electronic EngineeringDETECTORta115X-ray astronomy Silicon detectors timing spectroscopy010308 nuclear & particles physicsX-ray imagingX-ray timing; X-ray spectroscopy; X-ray imaging; compact objects; X-ray detectors; microchannel plates. PROPORTIONAL COUNTER ARRAY; CALIBRATION; DETECTORApplied MathematicNeutron starQB460-466 AstrophysicsSilicon detectors; spectroscopy; timing; X-ray astronomy; Electronic Optical and Magnetic Materials; Condensed Matter Physics; Computer Science Applications1707 Computer Vision and Pattern Recognition; Applied Mathematics; Electrical and Electronic EngineeringSilicon detectors; spectroscopy; timing; X-ray astronomySilicon detectorsLarge Observatory For x-ray Timing (LOFT) Large Area Detector (LAD) Wide Field Monitor (WFM) Large Area Silicon Drift Detectors (SDD)Gamma-ray burst
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