0000000000785629

AUTHOR

David E. Machugh

0000-0002-8112-4704

showing 2 related works from this author

A population genomics analysis of the native Irish Galway sheep breed.

2019

SUMMARYThe Galway sheep population is the only native Irish sheep breed and represents an important livestock genetic resource, which is currently categorised as “at-risk”. In the present study, comparative population genomics analyses of Galway sheep and other sheep populations of European origin were used to investigate the microevolution and recent genetic history of the breed. These analyses support the hypothesis that British Leicester sheep were used in the formation of the Galway breed and suggest more recent gene flow from the Suffolk sheep breed. When compared to conventional and endangered breeds, the Galway breed was intermediate in effective population size, genomic inbreeding a…

0301 basic medicine0106 biological sciencesAnimal breedingLivestocklcsh:QH426-470Populationbiology.animal_breedselection signaturePopulation geneticsZoologyinbreedingRuns of HomozygosityBiology010603 evolutionary biology01 natural sciencesGenetic diversityPopulation genomics03 medical and health sciences0302 clinical medicineEffective population sizesingle nucleotide polymorphismGeneticsInbreedingeducationGenetics (clinical)030304 developmental biologyOriginal Research2. Zero hunger0303 health scienceseducation.field_of_studybusiness.industryAt-risk breedat-risk breedgenetic diversitySelection signatureBreedSingle nucleotide polymorphismlivestocklcsh:Genetics030104 developmental biologyconservation genomics030220 oncology & carcinogenesisConservation genomicsSuffolk sheepMolecular MedicineLivestockFaculty of Science & Health AITbusinessInbreeding
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Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent

2019

Cattle were domesticated ∼10,000 years ago, but analysis of modern breeds has not elucidated their origins. Verdugo et al. performed genome-wide analysis of 67 ancient Near Eastern Bos taurus DNA samples. Several populations of ancient aurochs were progenitors of domestic cows. These genetic lineages mixed ∼4000 years ago in a region around the Indus Valley. Interestingly, mitochondrial analysis indicated that genetic material likely derived from arid-adapted Bos indicus (zebu) bulls was introduced by introgression.Science, this issue p. 173Genome-wide analysis of 67 ancient Near Eastern cattle, Bos taurus, remains reveals regional variation that has since been obscured by admixture in mode…

0301 basic medicine010506 paleontologyMitochondrial DNA[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory1103Human Migration12041105IntrogressionZoologyGenomics01 natural sciencesDNA Mitochondrial[SHS]Humanities and Social SciencesDomesticationEvolution Molecular03 medical and health sciencesBronze AgeAnimals[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]Domestication0105 earth and related environmental sciences[SDV.EE]Life Sciences [q-bio]/Ecology environment[SDV.GEN]Life Sciences [q-bio]/GeneticsMultidisciplinaryGenomebiologyHuman migrationbusiness.industryGenomicsAurochsZebubiology.organism_classificationhumanities030104 developmental biologyFertilityCattlebusiness
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