0000000000786540

AUTHOR

B Kirlin

showing 1 related works from this author

Genetic risk prediction and neurobiological understanding of alcoholism.

2014

We have used a translational Convergent Functional Genomics (CFG) approach to discover genes involved in alcoholism, by gene-level integration of genome-wide association study (GWAS) data from a German alcohol dependence cohort with other genetic and gene expression data, from human and animal model studies, similar to our previous work in bipolar disorder and schizophrenia. A panel of all the nominally significant P-value SNPs in the top candidate genes discovered by CFG  (n=135 genes, 713 SNPs) was used to generate a genetic  risk prediction score (GRPS), which showed a trend towards significance (P=0.053) in separating  alcohol dependent individuals from controls in an independent German…

AdultMaleRiskCandidate geneAlcohol abuseContext (language use)Single-nucleotide polymorphismGenome-wide association studyBioinformaticsPolymorphism Single NucleotideMice03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineGermanyAnimalsHumansMedicineGenetic Predisposition to DiseaseBiological Psychiatry030304 developmental biologyMice KnockoutGenetics0303 health sciencesbusiness.industryAlcohol dependenceGenomics16. Peace & justicemedicine.diseaseUnited States3. Good healthAlcoholismDisease Models AnimalPsychiatry and Mental healthBehavioral medicineCohortOriginal ArticleFemaleCorrigendumbusiness030217 neurology & neurosurgeryGenome-Wide Association Study
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