0000000000790956

AUTHOR

Grieco Antonio

showing 3 related works from this author

Neurotensin up-regulation is associated with advanced fibrosis and hepatocellular carcinoma in patients with MAFLD

2020

Background & aims: Neurotensin (NTS), a 13-aminoacid peptide localized in central nervous system and gastrointestinal tract, is involved in lipid metabolism and promotes various cancers onset mainly by binding to neurotensin receptor 1 (NTSR1). Increased plasma levels of pro-NTS, the stable NTS precursor, have been associated with type 2 diabetes (T2D), cardiovascular diseases and metabolic associated fatty liver disease (MAFLD). We aimed to evaluate 1) the impact of NTS rs1800832 and NTSR1 rs6090453 genetic variants on liver damage in 1166 MAFLD European individuals, 2) the relation between NTS variant and circulating pro-NTS and 3) the hepatic NTS expression by RNAseq transcriptomic a…

Male0301 basic medicineLiver damagemedicine.medical_specialtyGenetic variantsCarcinoma HepatocellularNeurotensin receptor 1CirrhosisTherapeutic targetSettore MED/12 - GASTROENTEROLOGIAType 2 diabetesGastroenterology03 medical and health sciencesLiver disease0302 clinical medicineFibrosisInternal medicinemedicineHumansReceptors NeurotensinBiomarker; Genetic variants; Lipid metabolism; Liver damage; Therapeutic targetMolecular BiologyNeurotensinAgedCell Proliferationbusiness.industryLiver NeoplasmsFatty liverBiomarker Genetic variants Lipid metabolism Liver damage Therapeutic targetCell BiologyBiomarkerMiddle Agedrespiratory systemmedicine.diseaseFibrosisFatty Liver030104 developmental biologyLipid metabolismDiabetes Mellitus Type 2Gene Expression Regulationnervous systemHepatocellular carcinomaMutationFemale030211 gastroenterology & hepatologybusinessHepatic fibrosiscirculatory and respiratory physiology
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Clinical Severity, Age, and Sex Overcome Cardiometabolic Morbidities but Not Stroke as Predictors of Mortality in Elderly Inpatients: Data From the R…

2016

MalePediatricsmedicine.medical_specialtyREPOSI studyClinical severity age stroke risk factors elderly REPOSI studySocio-culturale030204 cardiovascular system & hematologyAge and sexelderlySeverity of Illness Index03 medical and health sciencesSex Factors0302 clinical medicineMetabolic Diseasesmedicinerisk factorsHumansClinical severityClinical severityHospital MortalityRegistries030212 general & internal medicineStrokeAgedAged 80 and overInpatientsbusiness.industryAge Factorsmedicine.diseaseStrokeageItalyCardiovascular DiseasesFemaleMorbidityGeriatrics and GerontologybusinessJournal of the American Geriatrics Society
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Antipsychotic prescription and mortality in hospitalized older persons

2016

Background: Recent scientific reports have shown that older persons treated with antipsychotics for dementia-related behavioural symptoms have increased mortality. However, the impact of these drugs prescribed during hospitalization has rarely been assessed. We aimed to investigate whether antipsychotics are associated with an increased risk of mortality during hospitalization and at 3-month follow-up in elderly inpatients. Methods: We analyzed data gathered during two waves (2010 and 2012) by the REPOSI (Registro Politerapie Società Italiana Medicina Interna). All new prescriptions of antipsychotic drugs during hospitalization, whether maintained or discontinued at discharge, were collect…

MaleSocio-culturaleOlder personAntipsychoticCognitionEconomicaAntipsychotics; Hospitalization; Mortality; Older persons; Gerontology; Geriatrics and Gerontology; Psychiatry and Mental HealthHumansMortalityPsychomotor AgitationAgedantipsychotics hospitalization mortality older personsAged 80 and overMental DisordersPatient DischargeHospitalizationantipsychoticsItalyantipsychotics; hospitalization; mortality; older personsPsychiatry and Mental Healtholder personsDementiaFemaleGeriatrics and GerontologyGerontologyAntipsychotic Agents
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