Author: Tiziana Esposito

0000000000791190

AUTHOR

Tiziana Esposito

0000-0002-0330-8292

showing 1 related works from this author

Hop-derived fraction rich in beta acids and prenylflavonoids regulates the inflammatory response in dendritic cells differently from quercetin: unvei…

2021

Dendritic cells (DCs) represent a heterogeneous family of immune cells that link innate and adaptive immunity and their activation is linked to metabolic changes that are essential to support their activity and function. Hence, targeting the metabolism of DCs represents an opportunity to modify the inflammatory and immune response. Among the natural matrices, Humulus lupulus (Hop) compounds have recently been shown to exhibit immunomodulatory and anti-inflammatory activity. This study aimed to evaluate the ability of specific Hop fractions to modulate DCs metabolism after stimulation with lipopolysaccharide (LPS) by an untargeted metabolomics approach and compare their effect with flavonol …

LipopolysaccharideHop fractions Dendritic cells metabolomics analysis Nrf2/Nqo1 pathwayAnti-Inflammatory AgentsSuccinic AcidInbred C57BLMass SpectrometryProinflammatory cytokineHop (networking)chemistry.chemical_compoundMiceMetabolomicsImmune systemBone MarrowAnimalsMetabolomicsAnimals; Anti-Inflammatory Agents; Bone Marrow; Citrulline; Dendritic Cells; Disease Models Animal; Flavonoids; Humulus; Inflammation; Mass Spectrometry; Metabolomics; Mice; Mice Inbred C57BL; Plant Extracts; Purines; Pyrimidines; Quercetin; Succinic AcidHumulusFlavonoidsInflammationChemistryAnimalPlant ExtractsGeneral MedicineDendritic CellsAcquired immune systemSettore CHIM/08 - Chimica FarmaceuticaCell biologyMice Inbred C57BLDisease Models AnimalPyrimidinesPurinesDisease ModelsCitrullineTumor necrosis factor alphaQuercetinQuercetinFood ScienceFoodfunction

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PEPhysical Sciences and Engineering
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LSLife Sciences
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