0000000000794455
AUTHOR
M. Rosso
Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)
Introduction: Dementia with Lewy bodies (DLB) may represent a diagnostic challenge, since its clinical picture overlaps with other dementia. Two toolkits have been developed to aid the clinician to diagnose DLB: the Lewy Body Composite Risk Score (LBCRS) and the Assessment Toolkit for DLB (AT-DLB). We aim to evaluate the reliability of these two questionnaires, and their ability to enhance the interpretation of the international consensus diagnostic criteria. Methods: LBCRS and AT-DLB were distributed to 135 Italian Neurological Centers for Cognitive Decline and Dementia (CDCDs), with the indication to administer them to all patients with dementia referred within the subsequent 3 months. We…
Resveratrol from vine to wine
SPE IPM Biochemistry Research Trends Chapitre I; The stilbene compound resveratrol and its derivatives are produced by various plant families and possess a wide spectrum of interesting medical properties. In Vitaceae, these compounds are phytoalexins ie antifungal metabolites synthesized and accumulated in response to biotic or abiotic stresses. Therefore, even if their level in wines is influenced by winemaking process and fermentative micro-organisms, it largely depends on their initial level in berries. Resveratrol is synthesized via the phenylalanine / polymalonate pathway and can undergo glycosylation, methylation or polymerization, leading to a set of derivatives. Due to their distinc…
Visual and Hearing Impairment Are Associated With Delirium in Hospitalized Patients: Results of a Multisite Prevalence Study
Objective: Sensory deficits are important risk factors for delirium but have been investigated in single-center studies and single clinical settings. This multicenter study aims to evaluate the association between hearing and visual impairment or bi-sensory impairment (visual and hearing impairment) and delirium. Design: Cross-sectional study nested in the 2017 "Delirium Day" project. Setting and participants: Patients 65 years and older admitted to acute hospital medical wards, emergency departments, rehabilitation wards, nursing homes, and hospices in Italy. Methods: Delirium was assessed with the 4AT (a short tool for delirium assessment) and sensory deficits with a clinical evaluation. …