0000000000800392

AUTHOR

Valentina Kon

showing 2 related works from this author

Angiotensin type 2 receptor is important in the normal development of the ureter

1999

In humans, the actions of angiotensin II are transduced through the AT1 and AT2 receptors which have recently been implicated in renal organogenesis. Polymorphisms in the human angiotensin II receptor genes have been linked to cardiovascular and nephrological disorders. In this study we evaluated 35 patients with either primary obstructive megaureter or posterior urethral valves. Each was genotyped for the A1166 AT1 polymorphism and the recently described A-1332G AT2 transition. The incidence of these genetic variants was also evaluated in normal controls without any ultrasonographic urological abnormalities. Similar to our previous findings in congenital urological abnormalities, the AT1 r…

AdultMaleNephrologymedicine.medical_specialtyAngiotensin receptorAdolescentGenotypeMegaureterUrologyReceptor Angiotensin Type 2Receptor Angiotensin Type 1White PeopleGene FrequencyUrethraInternal medicineUrethral DiseasesmedicineHumansChildReceptorReceptors AngiotensinAngiotensin II receptor type 1business.industryCase-control studyInfantmedicine.diseaseAngiotensin IIEndocrinologyNephrologyChild PreschoolPediatrics Perinatology and Child HealthGene polymorphismUreterbusinesshormones hormone substitutes and hormone antagonistsUreteral ObstructionPediatric Nephrology
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Angiotensin II, type 2 receptor in the development of vesico-ureteric reflux

2001

Objective To investigate if mutation of the angiotensin II (Ang II) receptors AT2 is involved in primary vesico-ureteric reflux (VUR) in humans. Patients and methods Genetic polymorphisms in the AT1 and AT2 receptors was evaluated in 23 patients having the most common congenital urological abnormality, namely primary congenital VUR. The occurrence of the A1166C transition in the AT1 receptor gene and the A-1332G transition in the AT2 receptor gene were evaluated and compared with the incidence in normal controls with no urological abnormalities. Result The distribution of the AT1 receptor genotypes was no different between patients with VUR and healthy controls. Furthermore, 10 of 23 (44%) …

Pathologymedicine.medical_specialtyAngiotensin II receptor type 1business.industryMegaureterUrologyRefluxUrologyurologic and male genital diseasesmedicine.diseaseAngiotensin IIVesicoureteral refluxfemale genital diseases and pregnancy complicationsUretermedicine.anatomical_structurecardiovascular systemmedicineTrigone of urinary bladderReceptorbusinesshormones hormone substitutes and hormone antagonistscirculatory and respiratory physiologyBJU International
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