Author: Alice Monnier

0000000000802031

AUTHOR

Alice Monnier

Bdnf and Chronic Cerebral Hypoperfusion in Rats. Effects of Exercise

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Brain BDNF levels are dependent on cerebrovascular endothelium-derived nitric oxide

International audience; Scientific evidence continues to demonstrate a link between endothelial function and cognition. Besides, several studies have identified a complex interplay between nitric oxide (NO) and brain-derived neurotrophic factor (BDNF), a neurotrophin largely involved in cognition. Therefore, this study investigated the link between cerebral endothelium-derived NO and BDNF signaling. For this purpose, levels of BDNF and the phosphorylated form of endothelial NO synthase at serine 1177 (p-eNOS) were simultaneously measured in the cortex and hippocampus of rats subjected to either bilateral common carotid occlusion (n=6), physical exercise (n=6) or a combination of both (n=6) …

research product

Opposite effects of hypertension and physical exercise on cerebrovascular BDNF levels

International audience

research product

BDNF signaling and endothelial no production in rats subjected to physical training

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research product

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