0000000000802436
AUTHOR
Ming Sun
Shaken Snow Globes: Kinematic Tracers of the Multiphase Condensation Cascade in Massive Galaxies, Groups, and Clusters
We propose a novel method to constrain turbulence and bulk motions in massive galaxies, groups and clusters, exploring both simulations and observations. As emerged in the recent picture of the top-down multiphase condensation, the hot gaseous halos are tightly linked to all other phases in terms of cospatiality and thermodynamics. While hot halos (10^7 K) are perturbed by subsonic turbulence, warm (10^4 K) ionized and neutral filaments condense out of the turbulent eddies. The peaks condense into cold molecular clouds (< 100 K) raining in the core via chaotic cold accretion (CCA). We show all phases are tightly linked via the ensemble (wide-aperture) velocity dispersion along the line o…
Targeting the chromosomal passenger complex subunit INCENP induces polyploidization, apoptosis and senescence in neuroblastoma
Abstract Chromosomal passenger complex (CPC) has been demonstrated to be a potential target of cancer therapy by inhibiting Aurora B or survivin in different types of cancer including neuroblastoma. However, chemical inhibition of either Aurora B or survivin does not target CPC specifically due to off-target effects or CPC-independent activities of these two components. In a previous chromatin-focused siRNA screen, we found that neuroblastoma cells were particularly vulnerable to loss of INCENP, a gene encoding a key scaffolding component of the CPC. In this study, INCENP was highly expressed by neuroblastoma cells, and its expression decreased following retinoic acid–induced neuroblastoma …