0000000000803346

AUTHOR

Dieter Swatschek

showing 2 related works from this author

Microparticles derived from marine sponge collagen (SCMPs): preparation, characterization and suitability for dermal delivery of all-trans retinol.

2002

Abstract Collagen microparticles were prepared using marine sponge collagen. For this purpose a previous method by Rossler et al. (J. Microencapsul. 12 (1995) 49) of emulsification and cross-linking of native calf collagen was modified. The modified method for sponge collagen microparticles (SCMPs) achieved a yield of 10%. Scanning electromicroscopic photographs showed spherical particles with a diameter of 120–300 nm and photon correlation spectroscopic measurements indicated particle size range from 126 (±2.9) to 2179 (±342) nm. This broad size distribution was caused by some agglomerates that could not be destroyed by ultrasonication. The surface charge was measured as a function of pH. …

StereochemistrySonicationDrug CompoundingSkin AbsorptionPharmaceutical ScienceIn Vitro TechniquesAdministration CutaneousDosage formMiceDrug StabilityAnimalsAll trans retinolMicroparticleParticle SizeVitamin ADrug CarriersMice HairlessChromatographyChemistryGeneral MedicinePenetration (firestop)PoriferaSelf-healing hydrogelsFemaleParticle sizeCollagenDrug carrierBiotechnologyEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
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Marine sponge collagen: isolation, characterization and effects on the skin parameters surface-pH, moisture and sebum

2002

A previously described isolation procedure for collagen of the marine sponge Chondrosia reniformis Nardo was modified for scaling-up reasons yielding 30% of collagen (freeze-dried collagen in relation to freeze-dried sponge). Light microscope observations showed fibrous structures. Transmission electron microscopy studies proved the collagenous nature of this material: high magnifications showed the typical periodic banding-pattern of collagen fibres. However, the results of the amino acid analysis differed from most publications, presumably due to impurities that still were present. In agreement with earlier studies, sponge collagen was insoluble in dilute acid mediums and all solvents inv…

AdultMaleChemistry PharmaceuticalPharmaceutical ScienceDosage formlaw.inventionOptical microscopelawAnimalsHumansSolubilitySkinChromatographybiologyChemistryExtraction (chemistry)HumidityGeneral MedicineHydrogen-Ion ConcentrationMiddle Agedbiology.organism_classificationPoriferaSebumSpongeBiochemistryTransmission electron microscopyFemaleTitrationCollagenDispersion (chemistry)BiotechnologyEuropean Journal of Pharmaceutics and Biopharmaceutics
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