0000000000803867

AUTHOR

Gemma Xifra

showing 1 related works from this author

Genetic variations of the bitter taste receptor TAS2R38 are associated with obesity and impact on single immune traits

2015

Scope: Changes in genetic variations affecting the taste receptor, type 2, member 38 (TAS2R38) may identify the interacting mechanism leading to obesity and potential associations with proteins partaking in innate immunity, such as surfactant protein D (SPD) and mannan-binding lectin (MBL). Methods and results: We evaluated haplotypes of the bitter-taste receptor TAS2R38 in an identification sample of 210 women in different weight conditions, including anorexia nervosa and obesity. The association with SPD and MBL was tested in an independent sample picturing general population (n = 534). The relationship with obesity was validated in an extended final sample of 1319 participants. In the sa…

AdultMale0301 basic medicinemedicine.medical_specialtyAdolescentPopulation030209 endocrinology & metabolismSingle-nucleotide polymorphismBiologyMannose-Binding LectinPolymorphism Single NucleotideBody Mass IndexReceptors G-Protein-CoupledCohort StudiesYoung Adult03 medical and health sciences0302 clinical medicineInternal medicinemental disordersGenetic variationmedicineHumansObesityeducationAgedGeneticseducation.field_of_study030109 nutrition & dieteticsBody WeightSmokingHaplotypeGPR120Middle AgedPulmonary Surfactant-Associated Protein Dmedicine.diseaseObesityImmunity InnateTAS2R38EndocrinologyHaplotypesAnorexia nervosa (differential diagnoses)Case-Control StudiesTasteFemaleFood ScienceBiotechnologyMolecular Nutrition & Food Research
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