Author: Aida Nebot-guinot

0000000000805700

AUTHOR

Aida Nebot-guinot

Methylation as an effective way to generate SOD-activity in copper complexes of scorpiand-like azamacrocyclic receptors

Abstract Methylation of the secondary amine groups of a scorpiand-type ligand consisting of a pyridine spacer connected through methylene groups to a tris(2-aminomethyl) unit with the pendant arm further functionalised with a 3-pyridine unit leads to a ligand whose Cu(II) complex exhibits threefold enhanced SOD activity with respect to the non-methylated ligand. Potentiometric studies indicate the formation of [CuL] 2+ species with a stability three orders of magnitude lower than that formed with the related non-methylated ligand. Kinetic studies indicate that methylation of the secondary nitrogens causes a deceleration of both the complex formation and the acid-induced dissociation of the …

research product

CCDC 1559249: Experimental Crystal Structure Determination

Related Article: Aida Nebot-Guinot, Andrea Liberato, M. Angeles Máñez, M. Paz Clares, Antonio Doménech, Javier Pitarch-Jarque, Alvaro Martínez-Camarena, Manuel G. Basallote, Enrique García-España|2018|Inorg.Chim.Acta|472|139|doi:10.1016/j.ica.2017.08.044

research product

CCDC 1559236: Experimental Crystal Structure Determination

Related Article: Aida Nebot-Guinot, Andrea Liberato, M. Angeles Máñez, M. Paz Clares, Antonio Doménech, Javier Pitarch-Jarque, Alvaro Martínez-Camarena, Manuel G. Basallote, Enrique García-España|2018|Inorg.Chim.Acta|472|139|doi:10.1016/j.ica.2017.08.044

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PEPhysical Sciences and Engineering
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LSLife Sciences
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