Author: N. Haroon

0000000000805792

AUTHOR

N. Haroon

showing 1 related works from this author

FRI0158 Prostaglandin e2 and its receptor subtype ep4 are involved in ankylosing spondylitis disease progression

2018

Background Single Nucleotide Polymorphisms (SNPs) in PTGER4 were found to be associated with Ankylosing spondylitis (AS) in GWAS. PTGER4 codes for the prostaglandin-E2 receptor EP4. PGE2/EP4 interaction can affect bone formation and inflammation. Objectives We studied serum PGE2 levels and SNPs in PTGER4 in relation to spinal fusion in AS patients. We also evaluated the interaction of smoking, PGE2 and EP4 in driving IL23 production and ILC3 functions. Methods Patients diagnosed with AS using the modified New York criteria and followed prospectively using a standardised protocol, were included in this study. Biological samples including serum, gut, synovial and bone marrow (BM) samples, DNA…

Ankylosing spondylitisbusiness.industryMonocyteCD1405 social sciencesEP4 Receptor030204 cardiovascular system & hematologymedicine.diseasePeripheral blood mononuclear cell03 medical and health sciences0302 clinical medicinemedicine.anatomical_structure0502 economics and businessImmunologymedicineInterleukin 23lipids (amino acids peptides and proteins)050211 marketingbusinessReceptorBASDAIFRIDAY, 15 JUNE 2018

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