0000000000808194

AUTHOR

Man Xu

showing 2 related works from this author

Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection

2021

Human bocavirus 1 (HBoV1), a common pediatric respiratory pathogen, can persist in airway secretions for months hampering diagnosis. It also persists in tonsils, providing potential reservoirs for airway shedding, with the exact location, host cell types, and virus activity unknown.

NASOPHARYNXviruksetPalatine TonsilFc receptorCHILDRENvirus persistenceMonocytesHuman bocavirusCONGENITAL INSENSITIVITYBokavirusChildviruspersistenssi11832 Microbiology and virology0303 health sciencesB-LymphocytesbiologyHuman bocavirusvasta-aineetDENGUE-VIRUS-INFECTIONrespiratory systemMiddle AgedQR1-5023. Good healthLymphatic systemB-CELLSChild PreschoolAntibodyCELL-LINE U937HUMAN PARVOVIRUSResearch ArticleAdultAdolescentEndosomesMicrobiologyinfektiotVirusHost-Microbe BiologyParvoviridae Infections03 medical and health sciencesYoung AdultImmune systemnielurisaVirologytonsilsHumansAntibody-dependent enhancementRESPIRATORY VIRUSESparvovirukset030304 developmental biologyAgedRECEPTOR030306 microbiologyparvovirusInfant NewbornGerminal centerInfantbiology.organism_classificationGerminal CenterAntibody-Dependent Enhancementrespiratory tract diseasesgerminal centerImmunologyDNA Viralbiology.protein1182 Biochemistry cell and molecular biology3111 Biomedicinein situ hybridizationADEB-soluTRACTmBio
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Targeting the chromosomal passenger complex subunit INCENP induces polyploidization, apoptosis and senescence in neuroblastoma

2019

Abstract Chromosomal passenger complex (CPC) has been demonstrated to be a potential target of cancer therapy by inhibiting Aurora B or survivin in different types of cancer including neuroblastoma. However, chemical inhibition of either Aurora B or survivin does not target CPC specifically due to off-target effects or CPC-independent activities of these two components. In a previous chromatin-focused siRNA screen, we found that neuroblastoma cells were particularly vulnerable to loss of INCENP, a gene encoding a key scaffolding component of the CPC. In this study, INCENP was highly expressed by neuroblastoma cells, and its expression decreased following retinoic acid–induced neuroblastoma …

0301 basic medicineCancer ResearchINCENP/CPC/Polyploidy/DNA damage/Apoptosis/SenescenceCarcinogenesisChromosomal Proteins Non-HistoneAurora B kinaseApoptosisBiologymedicine.disease_causeArticlePolyploidy03 medical and health sciencesMiceNeuroblastoma0302 clinical medicineNeuroblastomaSurvivinmedicineGene silencingAnimalsHumansneoplasmsCellular SenescenceINCENPmedicine.disease030104 developmental biologyOncologyApoptosisTumor progression030220 oncology & carcinogenesisCancer researchHeterograftsCarcinogenesis
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