0000000000814980

AUTHOR

M. Von Bülow

showing 2 related works from this author

Histological and fine structural features of pancreatic ductal adenocarcinomas in relation to growth and prognosis: studies in xenografted tumours an…

1985

Histology and fine structure of pancreatic ductal adenocarcinomas were assessed with respect to their significance for tumour growth and prognosis. The histological parameters included glandular differentiation, nuclear anaplasia, nuclear size, and mitotic activity (number of mitoses per high power field). Using these criteria three grades of malignancy were distinguished. They correlated well with the growth kinetics of seven human pancreatic ductal adenocarcinomas transplanted into nude mice. The tumour doubling time of a G 3 carcinoma was about half that of a G 1 carcinoma. On electron microscopy the tumour grade was reflected in the degree of functional differentiation of the neoplastic…

AdultMaleAgingPathologymedicine.medical_specialtyTime FactorsHistologyMice Inbred StrainsBiologyMalignancyPathology and Forensic MedicineMiceSex FactorsmedicineCarcinomaAnimalsHumansDoubling timePostoperative PeriodGrading (tumors)AnaplasiaAgedNeoplasm StagingHigh-power fieldCell NucleusHistologyGeneral MedicineMiddle AgedPrognosismedicine.diseasePancreatic NeoplasmsKineticsCarcinoma Intraductal Noninfiltratingmedicine.anatomical_structureFemalemedicine.symptomPancreasCell DivisionNeoplasm TransplantationHistopathology
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Einfluß von Steroidhormonen auf das Wachstum exokriner Pankreascarcinome. In vivo- und in vitro-Untersuchungen

1987

In jungerer Zeit wurde in der Literatur uber eine mogliche Bedeutung von Steroidhormonen (SH) fur das Wachstum ductaler menschlicher Pankreascarcinome (PaCa) mehrfach berichtet (1, 2, 3). Auch die Steroidhormonkonzentration i.S. von Pankreascarcinomtragern scheint verandert zu sein (4). Um weitere Information uber den moglichen Einflus von Steroidhormonen auf das Wachstum von Pankreascarcinomen zu bekommen, wurden in dieser Arbeit folgende Fragen untersucht: 1. Lassen sich Steroidhormon-Receptoren in normalem Pankreas, in Gewebe von Pankreascarcinomen sowie in Gewebe transplantierter Pankreascarcinome auf der Nacktmaus nachweisen? 2. Lassen sich unterschiedliche Steroidhormon-Konzentratione…

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