0000000000824472

AUTHOR

Franco Giannini

showing 3 related works from this author

C9ORF72 in a Large Series of Italian and Sardinian Familial and Sporadic ALS Patients (IN9-1.003)

2012

Objective: To assess the frequency and the phenotype of a large series of Italian sALS and fALS with C9ORF72 repeat expansions. Background Recently we found that large expansions of hexanucleotide repeats (GGGGCC) in the first intron of the C9ORF72 gene, located in the chromosome 9p21, are related to familial and sporadic ALS cases(Renton et al, 2011). Design/Methods: We assessed 126 index fALS (106 Italians, 20 of Sardinians) and 601 sALS (485 Italians, 116 Sardinians), negative for other ALS-related genes mutations. Patients were collected through the ITALSGEN consortium. Repeat primer PCR to screen the presence of the hexanucleotide expansion in the first intron of C9ORF72 have been perf…

business.industryLarge seriesPedigree chartmedicine.diseasePenetranceC9orf72NothingAnticipation (genetics)MedicineNeurology (clinical)businessTrinucleotide repeat expansionDemographyFrontotemporal dementiaNeurology
researchProduct

Baseband predistorter using direct spline computation

2005

A baseband predistorter is presented. Key features of the predistorter reside in the use of cubic spline interpolation to generate predistorted input data to the power amplifier, without time convergence problems of classical approaches, with the goal of a reduction in the computational effort. Simulated behaviour of the proposed scheme is presented, demonstrating the effectiveness of the approach.

Engineeringbusiness.industryComputationAmplifierTransmitterSettore ING-INF/01 - ElettronicaSpline (mathematics)Rate of convergenceLinearizerBasebandElectronic engineeringElectrical and Electronic EngineeringbusinessSpline interpolationPredistorter baseband linearizer power amplifier spline
researchProduct

Harmonic solution of semiconductor transport equations for microwave and millimetre-wave device modelling

2004

The transport equations for charges in a semiconductor have been solved for a periodic voltage excitation by means of a harmonic approach, for modelling of microwave and millimetre-wave active devices. The solution is based on the expansion of the unknown physical quantities in Fourier series in the time domain, and on the discretisation in the space domain. A Waveform-Balance technique in the time domain is used to solve the resulting non-linear equations system. In this way the time step is determined only by Nyquist's sampling requirements at the operating frequency, irrespective of the relaxation times of the semiconductor. This approach allows for a longer time step, and therefore a sh…

PhysicsDiscretizationMathematical analysisRelaxation (iterative method)Computer Graphics and Computer-Aided DesignComputer Science ApplicationsSampling (signal processing)Electronic engineeringHarmonicING-INF/01 ElettronicaNyquist–Shannon sampling theoremhigh-frequency simulation semiconductorTime domainElectrical and Electronic EngineeringFourier seriesMicrowave
researchProduct