0000000000845446

AUTHOR

Corine Girard

0000-0002-5116-1395

showing 1 related works from this author

Cinnamaldehyde Induces Expression of Efflux Pumps and Multidrug Resistance in Pseudomonas aeruginosa

2019

Essential oils or their components are increasingly used to fight bacterial infections. Cinnamaldehyde (CNA), the main constituent of cinnamon bark oil, has demonstrated interesting properties in vitro against various pathogens, including Pseudomonas aeruginosa. In the present study, we investigated the mechanisms and possible therapeutic consequences of P. aeruginosa adaptation to CNA. Exposure of P. aeruginosa PA14 to subinhibitory concentrations of CNA caused a strong albeit transient increase in the expression of operons that encode the efflux systems MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY/OprM. This multipump activation enhanced from 2- to 8-fold the resistance (MIC) of PA14 to …

medicine.drug_classAntibioticsMicrobial Sensitivity Testsmedicine.disease_causeCinnamaldehydeMicrobiology03 medical and health scienceschemistry.chemical_compoundAntibiotic resistanceMechanisms of ResistanceDrug Resistance Multiple BacterialOils VolatilemedicineTobramycin[CHIM]Chemical SciencesPharmacology (medical)AcroleinComputingMilieux_MISCELLANEOUS030304 developmental biologyPharmacology0303 health sciences030306 microbiologyPseudomonas aeruginosaMembrane Transport Proteins[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biologybiochemical phenomena metabolism and nutrition[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciencesAnti-Bacterial Agents3. Good healthCiprofloxacinMultiple drug resistanceInfectious DiseaseschemistryPseudomonas aeruginosaEffluxmedicine.drug
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