De novo liquid biopsy and radio genomic diagnostic approach with combined deep learning artificial neural networks for NSCLC

Each year, the mortality rate and incidence of non-small cell lung cancer (NSCLC) are dramatically increasing. The introduction of liquid biopsy in the clinical practice of NSCLC has completely revolutionized the approach to such neoplasm since is generally detected through complex and invasive procedures and unfortunately at advanced stages. The importance and innovation of liquid biopsy are linked with the possibility of cancer detection at every stage, adjuvant treatment, resistance genotyping, systematic initiation of treatment, minimal residual disease, early detection of relapse, and screening of NSCLC. Circulating tumor DNA (ctDNA) is now emerging as a non-invasive biomarker that wil…