0000000000848543
AUTHOR
Vicente Guillem Porta
Más allá de la genética: Factores ambientales y cáncer
El cáncer es uno de los problemas sanitarios más importantes de los países occidentales, dada su alta incidencia y elevada mortalidad. Constituye la segunda causa de muerte después de las enfermedades cardiovasculares, y la primera causa en la población menor de 70 años. En este artículo nos ocuparemos de los factores externos capaces de inducir el desarrollo de un cáncer: agentes químicos, físicos y biológicos
Feasibility and tolerability of sequential doxorubicin/paclitaxel followed by cyclophosphamide, methotrexate, and fluorouracil and its effects on tumor response as preoperative therapy.
Abstract Purpose: The European Cooperative Trial in Operable breast cancer (ECTO) randomly tested whether efficacy of adjuvant doxorubicin followed by i.v. cyclophosphamide, methotrexate, and fluorouracil (CMF; doxorubicin → CMF, arm A) could be improved by adding paclitaxel (doxorubicin/paclitaxel → CMF) as adjuvant (arm B) or primary systemic therapy (PST, arm C). We report here feasibility, tolerability, locoregional antitumor activity, and breast conservation rate. Methods: A total of 1,355 women entered the study. Feasibility and safety were compared in arm A versus arms B plus C. Surgical findings were compared in arms A plus B versus arm C. Results: Grade 3 or 4 National Cancer Insti…
The future of precision medicine, strengths and weaknesses: An expert position paper.
e18879Background: Precision medicine (PM) is an emerging field. Guidelines are needed to develop this approach in an efficient and sustainable way. Methods: Twenty-one Spanish top oncologists met t...