Bisphosphonate-polyaspartamide conjugates as bone targeted drug delivery systems.

Poly-hydroxy-aspartamide was used as a backbone to synthesize bisphosphonate derivatives thus achieving macromolecular carriers to be potentially used as targeting agents for bone drug delivery. Molecules bearing bisphosphonate groups, such as aminobisphosphonate (ABP) and neridronate (NRD), have been conjugated to polyaspartamide (α,β-poly(N-2-hydroxyethyl)-dl-aspartamide, PHEA), with or without a spacer (succinic acid or 6-aminocaproic acid) thus obtaining PHEA-succinate-ABP and PHEA-caproylcarbamate-ABP and PHEA-ABP and PHEA-NRD, respectively. Bisphosphonate-polymer conjugates were physico-chemically characterized using size exclusion chromatography and 1H-NMR; and their in vitro and e…

Sistemi sopramolecolari cationici innovativi per la veicolazione polmonare dei bioattivi.

INNOVATIVE CATIONIC SUPRAMOLECULAR VESICULAR AGGREGATES (SVAs) FOR THE PULMONARY TISSUE SELECTIVE TARGETING

FOLATE RECEPTOR-TARGETED SUPRAMOLECULAR VESICULAR AGGREGATES (SVAS)FOR ANTICANCER THERAPY