0000000000851829
AUTHOR
Johannes Keller
The relation between human values and perceived situation characteristics in everyday life
Values refer to abstract beliefs which serve as guidelines in peoples’ life and affect the way people and events are evaluated. Simultaneously, unlike attitudes, values transcend specific actions, and situations. While recent research showed that values are related to the attention and interpretation of situational information in standardized laboratory settings, up to date hardly any empirical work investigated how values relate to situation perception in daily life. In our study, we assessed the relation between the endorsement of human values and situation characteristics (i.e., the 8 DIAMONDS). Using the Day Reconstruction Method in two samples (German and US-American), we found that es…
Epidermal IL-17A leads to bone loss through inhibition of osteoblast differentiation
The AP-1 transcription factor family is a central regulator of skin and bone homeostasis. We have previously shown that specific deletion of JunB/AP-1 in epidermis (JunBmice) results in skin inflammation,myeloproliferative disease, lupus-like disease and osteopenia. While upregulation of serum IL-6 and G-CSF are observed in this model, genetic deletion of these cytokines does not rescue osteopenia in JunB mice. Thus, we carried out a screen for other cytokines that are regulated by the loss of JunB in the epidermis. We have identified IL-17A as a cytokine expressed in JunB epidermis in vivo, and hypothesize that IL-17A leads to osteopenia in JunBmice. To test this,we carried out osteoblast …
Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts
Item does not contain fulltext Inflammation has important roles in tissue regeneration, autoimmunity, and cancer. Different inflammatory stimuli can lead to bone loss by mechanisms that are not well understood. We show that skin inflammation induces bone loss in mice and humans. In psoriasis, one of the prototypic IL-17A-mediated inflammatory human skin diseases, low bone formation and bone loss correlated with increased serum IL-17A levels. Similarly, in two mouse models with chronic IL-17A-mediated skin inflammation,K14-IL17A(ind)andJunB(Deltaep), strong inhibition of bone formation was observed, different from classical inflammatory bone loss where osteoclast activation leads to bone deg…