0000000000852312
AUTHOR
H. Kolb
Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis.
Islet cell antigen (ICA) 69 is a newly-recognized islet cell antigen to which autoantibodies have been observed in prediabetic relatives of patients with insulin-dependent-diabetes mellitus (IDDM). Here we extend the earlier analysis of ICA69 antibodies to patients with recent-onset IDDM and to patients with other immune-mediated diseases. ICA69 antibodies were determined by Western blot using an affinity purified recombinant fusion protein of ICA69 and maltose binding protein. ICA69 antibody quantities were determined as titres using a titration curve of a standard serum as reference. Mean logarithmic ICA69 antibody titres were 3.4 (+/- 1.4) in 99 patients with acute IDDM compared to 2.8 (…
Kontinenzverhalten nach Anal- und Rektumatresie und Lebensqualität
Inkontinenz, auch in partiellem Ausmas bedeutet immer eine Einschrankung der Lebensqualitat. In den verschiedenen Lebensabschnitten verandert sich die Leidensart. Beim Kleinkind steht der lokale Wundschmerz, im Schulalter die Beziehung zur Umwelt im Vordergrund. Beim Adoleszenten sind Berufsaussichten und Partnerschaftsbeziehungen eingeschrankt. Dem Kinderchirurgen kommt die Aufgabe zu, in einer subtilen Erstoperation, durch geeignete Korrekturverfahren und durch Forderung der psychologischen Entwicklung die Lebensqualitat entscheidend zu beeinflussen.
Genetic analysis of IDDM: The GAW5 multiplex family dataset
In a collaborative effort by 12 centers from Europe and North America, data were assembled from 94 multiplex families with insulin-dependent diabetes mellitus (IDDM) for analysis of genetic and other factors of possible etiological importance. The dataset contains information on the following genetic markers: HLA-DR beta and -DQ beta restriction fragment length polymorphisms (RFLPs), three RFLPs detected with two probes that map 5' to the insulin gene, the serologically defined HLA loci, and the immunoglobulin allotypes. Data also were included for auto-antibodies to insulin and pancreatic islet cells as possible indicators of pathogenesis and for antibodies to certain viruses that have bee…