Author: Layzon Antonio Lemos Da Silva

0000000000855155

AUTHOR

Layzon Antonio Lemos Da Silva

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ESI-MS2and Anti-inflammatory Studies of Cyclopropanic Triterpenes. UPLC-ESI-MS and MS2Search of Related Metabolites fromDonella ubanguiensis

2016

Introduction Triterpenes are one of the largest secondary metabolites groups spread in the plant kingdom with various skeletons. These metabolites have showed various bioactivities including anti-inflammatory activity. Objective The study aims to explore the mass spectrometry fragmentation of donellanic acids A-C (DA A–C), three compounds identified from Donella ubanguiensis; in addition, the fragmentation behaviour of these metabolites will serve as a fingerprint to search and characterise triterpenes congeners in fruits, bark and wood crude extracts of D. ubanguiensis. This work was prompted by the anti-inflammatory activity on leukocyte migration, exudate concentrations and myeloperoxida…

0301 basic medicineExudateLeukocyte migrationmedicine.drug_classPlant ScienceMass spectrometry01 natural sciencesBiochemistryAnti-inflammatoryAnalytical ChemistryTerpene03 medical and health scienceschemistry.chemical_compoundLiquid chromatography–mass spectrometryDrug DiscoverymedicineChromatography010405 organic chemistryChemistryGeneral Medicine0104 chemical sciencesCarrageenan030104 developmental biologyComplementary and alternative medicinevisual_artvisual_art.visual_art_mediumMolecular MedicineBarkmedicine.symptomFood SciencePhytochemical Analysis

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