PO-324 Detection of high-risk prostate cancer biomarkers by RNA sequencing and qPCR method

2018

Introduction New prognostic biomarkers for prostate cancer have the potential to overcome the clinical challenge of therapy decision and overtreatment. Present diagnostic and prognostic tests are still limited in specificity resulting in a large number of false positives and unnecessary biopsies. Furthermore, they do not enable a proper stratification between men with a high risk for an aggressive disease course requiring comprehensive therapy scheme after surgery and men with a low risk of disease recurrence cured after prostatectomy or eligible for active surveillance. In particular, patients with Gleason score 6 and 7 tumours (low and mid stage) are difficult to stratify for the appropri…