Author: Tj Cross

0000000000862806

AUTHOR

Tj Cross

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Digital image analysis of liver collagen predicts clinical outcome of recurrent hepatitis C virus 1 year after liver transplantation.

2011

Clinical outcomes of recurrent hepatitis C virus after liver transplantation are difficult to predict. We evaluated collagen proportionate area (CPA), a quantitative histological index, at 1 year with respect to the first episode of clinical decompensation. Patients with biopsies at 1 year after liver transplantation were evaluated by Ishak stage/grade, and biopsy samples stained with Sirius red for digital image analysis were evaluated for CPA. Cox regression was used to evaluate variables associated with first appearance of clinical decompensation. Receiver operating characteristic (ROC) curves were also used. A total of 135 patients with median follow-up of 76 months were evaluated. At 1…

AdultMaleTime FactorsAdolescentBiopsyHepatic Veins/physiopathologyKaplan-Meier EstimateLiver Cirrhosis/metabolism/pathology/physiopathology/*surgery/virologyRisk AssessmentSensitivity and Specificity*Image Interpretation Computer-AssistedYoung AdultPredictive Value of TestsRecurrenceRisk FactorsLondonHumansLiver/blood supply/*metabolism/pathology/*surgery/virologyChildAgedProportional Hazards ModelsRetrospective Studiesliver transplantationLiver Transplantation/*adverse effectsMiddle AgedROC CurveCollagen/*metabolismFemaleHepatitis C/complications/metabolism/pathology/physiopathology/*surgeryEnd Stage Liver Disease/pathology/physiopathology/*surgery/virologyVenous Pressure

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