0000000000866540
AUTHOR
Irene Salvo García
Phase I dose-escalation single centre clinical trial to evaluate the safety of infusion of memory T cells as adoptive therapy in COVID-19 (RELEASE)
Abstract Background Effective treatments are still needed to reduce the severity of symptoms, time of hospitalization, and mortality of COVID-19. SARS-CoV-2 specific memory T-lymphocytes obtained from convalescent donors recovered can be used as passive cell immunotherapy. Methods Between September and November 2020 a phase 1, dose-escalation, single centre clinical trial was conducted to evaluate the safety and feasibility of the infusion of CD45RA− memory T cells containing SARS-CoV-2 specific T cells as adoptive cell therapy against moderate/severe cases of COVID-19. Nine participants with pneumonia and/or lymphopenia and with at least one human leukocyte antigen (HLA) match with the don…
El mito de Icario en la General estoria de Alfonso X
This article studies the myth of Icarus as it is translated in the first part of Alfonso X's General estoria. Its analysis highlights aspects that are usually found in the mythographical episodes of the Alfonsine estoria, particularly linked with its possible sources and its internal characteristics. The latter ones are defined by the anonymity of the quote and an evident moral intention. Regarding the sources, if it is known that the mythography gets to the Alfonsine text through two paths, the gloss in the manuscripts and a mythographical work, the exact source or sources used by Alfonsine historians are still unidentified. I have begun searching where the elements that are found in no pr…