0000000000866687

AUTHOR

M. Witt

showing 2 related works from this author

Clinical outcomes and safety of rituximab treatment for patients with systemic lupus erythematosus (SLE) – results from a nationwide cohort in German…

2013

Objective The objective of this article is to evaluate the safety and clinical outcome of rituximab treatment in systemic lupus erythematosus (SLE) patients refractory to standard of care therapy in a real-life setting in Germany. Methods The GRAID registry included patients with different autoimmune diseases who were given off-label treatment with rituximab. Data on safety and clinical response were collected retrospectively. In SLE patients, clinical parameters included tender and swollen joint counts, fatigue, myalgia, general wellbeing, Raynaud’s and the SLEDAI index. Laboratory tests included dsDNA antibody titres, complement factors, hematologic parameters and proteinuria. Finally, th…

AdultMalemyalgiamedicine.medical_specialty610 MedizinCohort StudiesAntibodies Monoclonal Murine-DerivedRheumatologyRefractoryInternal medicineHumansLupus Erythematosus SystemicMedicineIn patientskin and connective tissue diseasesRetrospective Studiesddc:610Proteinuriabusiness.industryOff-Label UseSystemic lupus erythematosus; rituximab; efficacy; safety;Blymphocytes; cohort studiesDiscontinuationCohortPhysical therapyFemaleRituximabmedicine.symptomRituximabbusinessCohort studymedicine.drugLupus
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An international registry for primary ciliary dyskinesia

2016

Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder leading to chronic upper and lower airway disease. Fundamental data on epidemiology, clinical presentation, course and treatment strategies are lacking in PCD. We have established an international PCD registry to realise an unmet need for an international platform to systematically collect data on incidence, clinical presentation, treatment and disease course.The registry was launched in January 2014. We used internet technology to ensure easy online access using a web browser under www.pcdregistry.eu. Data from 201 patients have been collected so far. The database is comprised of a basic data form including demographic…

0301 basic medicineMalePediatricsDiseaseMedical and Health Sciences0302 clinical medicineForced Expiratory VolumeEpidemiologyMedicineCorticosteroidRegistriesYoung adult610 Medicine & healthChildIntersectoral Collaborationhealth care economics and organizationsPrimary ciliary dyskinesiaΑntibiotic agentIncidence (epidemiology)IncidenceMiddle AgedEuropeChild PreschoolDisease ProgressionFemale360 Social problems & social servicesHumanPulmonary and Respiratory MedicineAdultmedicine.medical_specialtyAdolescenteducationMEDLINE03 medical and health sciencesYoung AdultAge Distributionotorhinolaryngologic diseasesHumansAgedInternetbusiness.industryKartagener SyndromePatient SelectionInfantmedicine.diseaserespiratory tract diseases030104 developmental biology030228 respiratory systemOther Medical SciencesNorth AmericaResearch studiesObservational studyBronchodilating agentbusiness
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