0000000000867355

AUTHOR

Francesco Borgia

showing 3 related works from this author

Prevalence and risk factors of actinic keratosis in patients attending Italian dermatology clinics

2017

Background: Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia. Objective: To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. Materials & methods: This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented. Results: AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK ris…

Complete datamedicine.medical_specialtySkin typeskin neoplasmseuropean continental ancestry groupWhite People030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicinemaleRetrospective Studiemiddle agedmedicinePrevalenceIn patientSkin NeoplasmRisk factorhumansMale genderEntire populationbusiness.industryActinic keratosiRisk FactoradultActinic keratosisambulatory care facilitiesRetrospective cohort studymedicine.diseaseDermatologyAmbulatory Care FacilitieKeratosis Actinicdermatologyagedretrospective studiesactinic keratosis; Italy; prevalence; risk factors; adult; aged; ambulatory care facilities; dermatology; european continental ancestry group; female; humans; keratosis actinic; male; middle aged; prevalence; retrospective studies; risk factors; skin neoplasmsfemaleItalyRisk factors030220 oncology & carcinogenesisActinic keratosis; Italy; Prevalence; Risk factorskeratosisActinic keratosis; Italy; Prevalence; Risk factors; 2708actinicActinic keratosisbusinessSettore MED/35 - MALATTIE CUTANEE E VENEREEHuman2708
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Normal reference values of multilayer longitudinal strain according to age decades in a healthy population: A single-centre experience.

2017

Aims Recent advancements in echocardiographic technology allow to analyse myocardial strain in multiple layers. Little is known about the impact of age on layer-specific longitudinal strain in healthy subjects. The aim of this study was to analyse the influence of age on multilayer longitudinal strain and establish normal reference values of layer-specific strain according to age decades in a healthy population referring to our echo laboratory using 2D speckle-tracking echocardiography with layer-specific software. Methods and results Two-hundred sixty-six healthy, consecutive subjects (mean age = 39.2 ± 17.5 years, women/men = 137/129), free of cardiovascular risk factors, were enrolled. S…

AdultMalemedicine.medical_specialtyLongitudinal strain030204 cardiovascular system & hematologyVentricular Function LeftCohort Studies03 medical and health sciences0302 clinical medicineReference ValuesInternal medicineLinear regressionImage Interpretation Computer-AssistedmedicineHumansRadiology Nuclear Medicine and imaging030212 general & internal medicineProspective StudiesProspective cohort studyObserver VariationStrain (chemistry)business.industrysubendocardial strainConfoundingsubepicardial strainAge FactorsStroke VolumeGeneral MedicineMiddle AgedHealthy VolunteersageingAgeingEchocardiographyReference valuesCardiologyLinear ModelsFemaleCardiology and Cardiovascular Medicinebusinessglobal longitudinal strainglobal longitudinal strain subepicardial strain subendocardial strain echocardiography ageingCohort studyEuropean heart journal. Cardiovascular Imaging
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Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure

2008

AIMS: Recent studies have demonstrated the importance of chromatin remodelling via histone acetylation/deacetylation for the control of cardiac gene expression. Specific histone deacetylases (HDACs) can, in fact, play a positive or negative role in determining cardiac myocyte (CM) size. Here, we report on the effect on hypertrophy development of three inhibitors (HDACi) of class I HDACs. METHODS AND RESULTS: The compounds were first analysed in vitro by scoring hypertrophy, expression of foetal genes, and apoptosis of neonatal rat CMs stimulated with phenylephrine, an alpha1-adrenergic agonist. This initial screening indicated that a truncated derivative of apicidin with class I HDAC specif…

Cardiac function curvemedicine.medical_specialtyHypertrophy Heart failurePhysiologymedicine.drug_classBiologyPeptides CyclicHistone DeacetylasesCell LineMuscle hypertrophychemistry.chemical_compoundPhysiology (medical)Internal medicinemedicineAnimalsHumansMyocytes CardiacEnzyme InhibitorsRats WistarCells CulturedHeart FailurePressure overloadHistone deacetylase inhibitorHypertrophic cardiomyopathyHypertrophymedicine.diseaseRatsHistone Deacetylase InhibitorsDisease Models AnimalEndocrinologychemistryEchocardiographyHeart failureHypertrophy Left VentricularHistone deacetylaseCardiology and Cardiovascular MedicineApicidinCardiovascular Research
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